The MDM2-binding region in the transactivation domain of p53 also acts as a Bcl-XL-binding motif

• Main Authors: Xu, Huibin, Ye, Hong, Osman, Nur Eliza, Sadler, Kristen, Won, Eun-Young, Chi, Seung-Wook, Yoon, Ho Sup
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2012
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: https://hdl.handle.net/10356/93855; http://hdl.handle.net/10220/7476
• Institution: Nanyang Technological University

While the transcription-dependent mechanism of p53 has been extensively studied, recently the transcription-independent apoptotic activity of p53 has also been described. Bcl-2 and Bcl-XL interact with p53 and induce apoptosis. Initially, the p53 DNA-binding domain (p53DBD) was found to bind to Bcl-...