Domain 2 of non-structural protein 5A (NS5A) of hepatitis C virus is natively unfolded

• Main Authors: Liang, Yu, Ye, Hong, Kang, Cong Bao, Yoon, Ho Sup
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2012
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Virology
• Online Access: https://hdl.handle.net/10356/94173; http://hdl.handle.net/10220/7474
• Institution: Nanyang Technological University

Nonstructural protein 5A protein (NS5A) of hepatitis C virus (HCV) plays an important role in the regulation of viral replication, interferon resistance, and apoptosis. HCV NS5A comprises three domains. Recently the structure of domain 1 has been determined, revealing a structural scaffold with a no...