Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors

Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors

The authors study deoxyribonucleic acid (DNA) sensing characteristics of carbon nanotube network...

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Main Authors: Rogers, John A., Gui, Ee Ling, Li, Lain-Jong, Lee, Pooi See, Lohani, Anup, Mhaisalkar, Subodh Gautam, Cao, Qing, Kang, Seong Jun, Tansil, Natalia Chendrawati, Gao, Zhiqiang
Other Authors: School of Materials Science & Engineering
Format: Article
Language:English
Published: 2012
Subjects:
DRNTU::Engineering::Materials::Nanostructured materials
Online Access:https://hdl.handle.net/10356/94252
http://hdl.handle.net/10220/8095
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-942522023-07-14T15:53:40Z Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors Rogers, John A. Gui, Ee Ling Li, Lain-Jong Lee, Pooi See Lohani, Anup Mhaisalkar, Subodh Gautam Cao, Qing Kang, Seong Jun Tansil, Natalia Chendrawati Gao, Zhiqiang School of Materials Science & Engineering DRNTU::Engineering::Materials::Nanostructured materials The authors study deoxyribonucleic acid (DNA) sensing characteristics of carbon nanotube network field-effect transistors (CNNFETs) by monitoring their electrical responses upon immobilization with a DNA probe, hybridization with DNA analytes, and intercalation with a N,N'-bis(3-propylimidazole)-1,4,5,8-naphthalene diimide modified with Os(2,2'-bipyridine)2Cl+ pendants. The CNNFETs immobilized by single-stranded DNA molecules demonstrate the selective sensing of its complementary and single-base mismatched DNA (difference of ~16% in reduction of normalized drain current Id). Subsequent intercalation demonstrates a further sensitivity enhancement (difference of ~13% in Id reduction due to specific binding between hybridized DNA and intercalators, corroborated by the x-ray photoelectron spectroscopy study. Published version 2012-05-18T07:08:45Z 2019-12-06T18:53:16Z 2012-05-18T07:08:45Z 2019-12-06T18:53:16Z 2006 2006 Journal Article Gui, E. L., Li, L. J., Lee, P. S., Lohani, A., Mhaisalkar, S. G., Cao, Q., et al. (2006). Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field effect transistors. Applied physics letters, 89(23). https://hdl.handle.net/10356/94252 http://hdl.handle.net/10220/8095 10.1063/1.2399355 en Applied physics letters © 2006 American Institute of Physics. This paper was published in Applied Physics Letters and is made available as an electronic reprint (preprint) with permission of American Institute of Physics. The paper can be found at the following official URL: http://dx.doi.org/10.1063/1.2399355. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. 3 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Materials::Nanostructured materials
spellingShingle DRNTU::Engineering::Materials::Nanostructured materials
Rogers, John A.
Gui, Ee Ling
Li, Lain-Jong
Lee, Pooi See
Lohani, Anup
Mhaisalkar, Subodh Gautam
Cao, Qing
Kang, Seong Jun
Tansil, Natalia Chendrawati
Gao, Zhiqiang
Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors
author2 School of Materials Science & Engineering
author_facet School of Materials Science & Engineering
Rogers, John A.
Gui, Ee Ling
Li, Lain-Jong
Lee, Pooi See
Lohani, Anup
Mhaisalkar, Subodh Gautam
Cao, Qing
Kang, Seong Jun
Tansil, Natalia Chendrawati
Gao, Zhiqiang
format Article
author Rogers, John A.
Gui, Ee Ling
Li, Lain-Jong
Lee, Pooi See
Lohani, Anup
Mhaisalkar, Subodh Gautam
Cao, Qing
Kang, Seong Jun
Tansil, Natalia Chendrawati
Gao, Zhiqiang
author_sort Rogers, John A.
title Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors
title_short Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors
title_full Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors
title_fullStr Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors
title_full_unstemmed Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors
title_sort electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors
publishDate 2012
url https://hdl.handle.net/10356/94252
http://hdl.handle.net/10220/8095
_version_ 1772826644631781376
description The authors study deoxyribonucleic acid (DNA) sensing characteristics of carbon nanotube network field-effect transistors (CNNFETs) by monitoring their electrical responses upon immobilization with a DNA probe, hybridization with DNA analytes, and intercalation with a N,N'-bis(3-propylimidazole)-1,4,5,8-naphthalene diimide modified with Os(2,2'-bipyridine)2Cl+ pendants. The CNNFETs immobilized by single-stranded DNA molecules demonstrate the selective sensing of its complementary and single-base mismatched DNA (difference of ~16% in reduction of normalized drain current Id). Subsequent intercalation demonstrates a further sensitivity enhancement (difference of ~13% in Id reduction due to specific binding between hybridized DNA and intercalators, corroborated by the x-ray photoelectron spectroscopy study.

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