Stapled BH3 Peptides against MCL-1 : mechanism and design using atomistic simulations

Stapled BH3 Peptides against MCL-1 : mechanism and design using atomistic simulations

Atomistic simulations of a set of stapled alpha helical peptides derived from the BH3 helix of MCL-1 (Stewart et al. (2010) Nat Chem Biol 6: 595–601) complexed to a fragment (residues 172–320) of MCL-1 revealed that the highest affinity is achieved when the staples engage the surface of MCL-1 as has...

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書目詳細資料
Main Authors:	Joseph, Thomas L., Lane, David P., Verma, Chandra Shekhar.
其他作者:	School of Biological Sciences
格式:	Article
語言:	English
出版:	2013
在線閱讀:	https://hdl.handle.net/10356/95173 http://hdl.handle.net/10220/9289
標簽:	添加標簽沒有標簽, 成為第一個標記此記錄!

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