Physical organization of DNA by multiple non-specific DNA-binding modes of integration host factor (IHF)

• Main Authors: Lin, Jie, Chen, Hu, Dröge, Peter, Yan, Jie
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Genetics
• Online Access: https://hdl.handle.net/10356/95346; http://hdl.handle.net/10220/9317
• Institution: Nanyang Technological University

The integration host factor (IHF) is an abundant nucleoid-associated protein and an essential co-factor for phage λ site-specific recombination and gene regulation in E. coli. Introduction of a sharp DNA kink at specific cognate sites is critical for these functions. Interestingly, the intracellular...