Thermal desorption behavior and binding properties of DNA bases and nucleosides on gold
A comparison of the binding of DNA bases (adenine, cytosine, guanine, and thymine) and nucleosides (2‘deoxyadenosine, 2‘deoxycytidine, 2‘deoxyguanosine, and thymidine) to gold thin films is presented. Desorption of monolayer/submonolayer and multilayer films of the adsorbates on gold studied via tem...
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sg-ntu-dr.10356-954872020-06-01T10:26:41Z Thermal desorption behavior and binding properties of DNA bases and nucleosides on gold Demers, Linette M. Mirkin, Chad A. Östblom, Mattias Zhang, Hua Jang, Nak-Han Liedberg, Bo School of Materials Science & Engineering DRNTU::Engineering::Materials A comparison of the binding of DNA bases (adenine, cytosine, guanine, and thymine) and nucleosides (2‘deoxyadenosine, 2‘deoxycytidine, 2‘deoxyguanosine, and thymidine) to gold thin films is presented. Desorption of monolayer/submonolayer and multilayer films of the adsorbates on gold studied via temperature-programmed desorption (TPD) and reflection−absorption infrared (RAIR) spectroscopy reveals that there are major differences in the binding affinities of the different bases to gold, for example, thymine ΔHdes = 111 ± 2 kJ/mol compared to guanine ΔHdes = 146 ± 2 kJ/mol. The differences can be rationalized by molecular structures of the bases and their binding modes to gold surfaces deduced from IR data. Similar trends in desorption energies, shifted to lower desorption energy by more than 10 kJ/mol, are observed for deoxynucleoside layers on gold thin films. 2012-09-19T08:02:28Z 2019-12-06T19:15:50Z 2012-09-19T08:02:28Z 2019-12-06T19:15:50Z 2002 2002 Journal Article Demers, L. M., Östblom, M., Zhang, H., Jang, N. H., Liedberg, B., & Mirkin, C. A. (2002). Thermal Desorption Behavior and Binding Properties of DNA Bases and Nucleosides on Gold. Journal of the American Chemical Society, 124(38), 11248-11249. 0002-7863 https://hdl.handle.net/10356/95487 http://hdl.handle.net/10220/8576 10.1021/ja0265355 en Journal of the American chemical society © 2002 American Chemical Society. |
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DRNTU::Engineering::Materials Demers, Linette M. Mirkin, Chad A. Östblom, Mattias Zhang, Hua Jang, Nak-Han Liedberg, Bo Thermal desorption behavior and binding properties of DNA bases and nucleosides on gold |
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A comparison of the binding of DNA bases (adenine, cytosine, guanine, and thymine) and nucleosides (2‘deoxyadenosine, 2‘deoxycytidine, 2‘deoxyguanosine, and thymidine) to gold thin films is presented. Desorption of monolayer/submonolayer and multilayer films of the adsorbates on gold studied via temperature-programmed desorption (TPD) and reflection−absorption infrared (RAIR) spectroscopy reveals that there are major differences in the binding affinities of the different bases to gold, for example, thymine ΔHdes = 111 ± 2 kJ/mol compared to guanine ΔHdes = 146 ± 2 kJ/mol. The differences can be rationalized by molecular structures of the bases and their binding modes to gold surfaces deduced from IR data. Similar trends in desorption energies, shifted to lower desorption energy by more than 10 kJ/mol, are observed for deoxynucleoside layers on gold thin films. |
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School of Materials Science & Engineering |
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School of Materials Science & Engineering Demers, Linette M. Mirkin, Chad A. Östblom, Mattias Zhang, Hua Jang, Nak-Han Liedberg, Bo |
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Article |
author |
Demers, Linette M. Mirkin, Chad A. Östblom, Mattias Zhang, Hua Jang, Nak-Han Liedberg, Bo |
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Demers, Linette M. |
title |
Thermal desorption behavior and binding properties of DNA bases and nucleosides on gold |
title_short |
Thermal desorption behavior and binding properties of DNA bases and nucleosides on gold |
title_full |
Thermal desorption behavior and binding properties of DNA bases and nucleosides on gold |
title_fullStr |
Thermal desorption behavior and binding properties of DNA bases and nucleosides on gold |
title_full_unstemmed |
Thermal desorption behavior and binding properties of DNA bases and nucleosides on gold |
title_sort |
thermal desorption behavior and binding properties of dna bases and nucleosides on gold |
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2012 |
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https://hdl.handle.net/10356/95487 http://hdl.handle.net/10220/8576 |
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1681059361406844928 |