Intrinsic differences between authentic and cryptic 5' splice sites

• Main Authors: Krainer, Adrian R., Sachidanandam, Ravi, Roca, Xavier
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2012
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/95535; http://hdl.handle.net/10220/8876
• Institution: Nanyang Technological University

Cryptic splice sites are used only when use of a natural splice site is disrupted by mutation. To determine the features that distinguish authentic from cryptic 5′ splice sites (5′ss), we systematically analyzed a set of 76 cryptic 5′ss derived from 46 human genes. These cryptic 5′ss have a similar...