The molecular basis of distinct aggregation pathways of islet amyloid polypeptide

• المؤلفون الرئيسيون: Chan-Park, Mary B., Wei, Lei, Jiang, Ping, Xu, Weixin, Li, Hai, Zhang, Hua, Yan, Liang Yu, Liu, Xue-Wei, Tang, Kai, Mu, Yuguang, Pervushin, Konstantin
• مؤلفون آخرون: School of Materials Science & Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2012
• الموضوعات: DRNTU::Science::Biological sciences::Biochemistry
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/95683; http://hdl.handle.net/10220/8323
• المؤسسة: Nanyang Technological University

Abnormal aggregation of islet amyloid polypeptide (IAPP) into amyloid fibrils is a hallmark of type 2 diabetes. In this study, we investigated the initial oligomerization and subsequent addition of monomers to growing aggregates of human IAPP at the residue-specific level using NMR, atomic force mic...