Dynamics of Bcl-xL in water and membrane : molecular simulations

• Main Authors: Maity, Atanu., Yadav, Seema., Verma, Chandra S., Dastidar, Shubhra Ghosh.
• Other Authors: Fraternali, Franca.
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/95870; http://hdl.handle.net/10220/18381
• Institution: Nanyang Technological University

The Bcl2 family of proteins is capable of switching the apoptotic machinery by directly controlling the release of apoptotic factors from the mitochondrial outer membrane. They have ‘pro’ and ‘anti’-apoptotic subgroups of proteins which antagonize each other’s function; however a detailed atomistic...