Cancer stem cell tumor model reveals invasive morphology and increased phenotypical heterogeneity

• Main Authors: Sottoriva, Andrea, Verhoeff, Joost J. C., Borovski, Tijana, McWeeney, Shannon, Naumov, Lev, Medema, Jan Paul, Sloot, Peter M. A., Vermeulen, Louis
• Other Authors: School of Computer Engineering
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/96024; http://hdl.handle.net/10220/10119
• Institution: Nanyang Technological University

The recently developed concept of cancer stem cells (CSC) sheds new light on various aspects of tumor growth and progression. Here, we present a mathematical model of malignancies to investigate how a hierarchical organized cancer cell population affects the fundamental properties of solid malignanc...