Catalytic enantioselective conjugate addition of grignard reagents to cyclic enones using C 1 -1,1′-bisisoquinoline-based chiral ligands

• Main Authors: Judeh, Zaher M. A., Qi, Gao
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/96144; http://hdl.handle.net/10220/11770
• Institution: Nanyang Technological University

New highly constrained chiral C1-1,10-bisisoquinoline ligands were examined in the enantioselective conjugate addition of Grignard reagents to cyclohexenone and cyclopentenone. The desired 1,4-adducts were obtained in excellent yield and moderate enantiomeric excess (up to 35%).