Ferrocenyl catechols : synthesis, oxidation chemistry and anti-proliferative effects on MDA-MB-231 breast cancer cells

• Main Authors: Hillard, Elizabeth A., Tan, Kelvin Yong Leng, Pigeon, Pascal, Top, Siden, Labbé, Eric, Buriez, Olivier, Vessières, Anne, Amatore, Christian, Leong, Weng Kee, Jaouen, Gérard
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/96342; http://hdl.handle.net/10220/10868
• Institution: Nanyang Technological University

The synthesis and anti-tumoral properties of a series of compounds possessing a ferrocenyl group tethered to a catechol via a conjugated system is presented. On MDA-MB-231 breast cancer cell lines, the catechol compounds display a similar or greater anti-proliferative potency (IC50 values ranging fr...