Nanofiber-mediated controlled release of siRNA complexes for long term gene-silencing applications

• Main Authors: Rujitanaroj, Pim-On, Wang, Yu-Cai, Wang, Jun, Chew, Sing Yian
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Medicine::Biomedical engineering
• Online Access: https://hdl.handle.net/10356/96598; http://hdl.handle.net/10220/9974
• Institution: Nanyang Technological University

Nanofiber scaffold-mediated delivery of small-interfering RNA (siRNA) holds great potential in regenerative medicine by providing biomimicking topographical signals and enhanced gene silencing effects to seeded cells. While the delivery of naked siRNA was demonstrated previously using poly (ε-caprol...