Negative auto-regulation of myostatin expression is mediated by SMAD3 and microRNA-27

• Main Authors: Ge, XiaoJia, McFarlane, Craig, Vajjala, Anuradha, Arigela, Harikumar, Lokireddy, Sudarsanareddy, Bonala, Sabeera, Manickam, Ravikumar, Kambadur, Ravi, Sharma, Mridula
• Other Authors: Lee, Se-Jin
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/97786; http://hdl.handle.net/10220/19609
• Institution: Nanyang Technological University

Growth factors, such as myostatin (Mstn), play an important role in regulating post-natal myogenesis. In fact, loss of Mstn has been shown to result in increased post-natal muscle growth through enhanced satellite cell functionality; while elevated levels of Mstn result in dramatic skeletal muscle w...