Lack of Smad3 signaling leads to impaired skeletal muscle regeneration

• Main Authors: Sharma, Mridula, McFarlane, Craig, Wahli, Walter, Ge, Xiaojia, Vajjala, Anuradha, Kambadur, Ravi
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/98518; http://hdl.handle.net/10220/12445
• Institution: Nanyang Technological University

Smad3 is a key intracellular signaling mediator for both transforming growth factor-β and myostatin, two major regulators of skeletal muscle growth. Previous published work has revealed pronounced muscle atrophy together with impaired satellite cell functionality in Smad3-null muscles. In the presen...