Comparison of Internal Ribosome Entry Site (IRES) and Furin-2A (F2A) for monoclonal antibody expression level and quality in CHO cells

Comparison of Internal Ribosome Entry Site (IRES) and Furin-2A (F2A) for monoclonal antibody expression level and quality in CHO cells

Four versions of tricistronic vectors expressing IgG1 light chain (LC), IgG1 heavy chain (HC), and dihydrofolate reductase (DHFR) in one transcript were designed to compare internal ribosome entry site (IRES) and furin-2A (F2A) for their influence on monoclonal antibody (mAb) expression level and qu...

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Bibliographic Details
Main Authors: Bardor, Muriel, Li, Bin, Lee, Jia Juan, Song, Zhiwei, Tong, Yen Wah, Goh, Lin-Tang, Yang, Yuansheng, Ho, Steven C. L.
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/97890
http://hdl.handle.net/10220/13223
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/97890
http://hdl.handle.net/10220/13223

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