A synthetic polyphosphoinositide headgroup surrogate in complex with SHIP2 provides a rationale for drug discovery

• Main Authors: Persson, Camilla, Cozier, Gyles, Trésaugues, Lionel, Erneux, Christophe, Nordlund, Pär, Mills, Stephen J., Thomas, Mark P., Riley, Andrew M., Potter, Barry V. L.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/97967; http://hdl.handle.net/10220/12267
• Institution: Nanyang Technological University

Phosphoinositides regulate many cellular processes, and cellular levels are controlled by kinases and phosphatases. SHIP2 (SH2 (Src homology 2)-domain-containing inositol-phosphatase-2) plays a critical role in phosphoinositide signaling, cleaving the 5-phosphate from phosphatidylinositol 3,4,5-tris...