Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment

Edible: By grafting natural peptide antagonists onto the cyclotide kalata B1, orally active peptides were engineered, which are potentially useful therapeutics for the treatment of inflammatory pain. For example, the entire loop 6 of kalata B1 was replaced with the peptidic bradykinin B1 receptor an...

Full description

Saved in:

Bibliographic Details
Main Authors:	Wong, Clarence T. T., Rowlands, Dewi K., Wong, Chi-Hang., Lo, Theodore W. C., Nguyen, Giang K. T., Li, Hoi-Yeung, Tam, James P.
Other Authors:	School of Biological Sciences
Format:	Article
Language:	English
Published:	2013
Subjects:	DRNTU::Science::Biological sciences
Online Access:	https://hdl.handle.net/10356/98385 http://hdl.handle.net/10220/12497
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	Nanyang Technological University
Language:	English

id	sg-ntu-dr.10356-98385
record_format	dspace
spelling	sg-ntu-dr.10356-983852020-03-07T12:18:20Z Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment Wong, Clarence T. T. Rowlands, Dewi K. Wong, Chi-Hang. Lo, Theodore W. C. Nguyen, Giang K. T. Li, Hoi-Yeung Tam, James P. School of Biological Sciences DRNTU::Science::Biological sciences Edible: By grafting natural peptide antagonists onto the cyclotide kalata B1, orally active peptides were engineered, which are potentially useful therapeutics for the treatment of inflammatory pain. For example, the entire loop 6 of kalata B1 was replaced with the peptidic bradykinin B1 receptor antagonist DALK (red in scheme) to obtain the cyclic bradykinin antagonist ckb-kal. 2013-07-29T08:18:14Z 2019-12-06T19:54:39Z 2013-07-29T08:18:14Z 2019-12-06T19:54:39Z 2012 2012 Journal Article Wong, C. T. T., Rowlands, D. K., Wong, C.-H., Lo, T. W. C., Nguyen, G. K. T., Li, H.-Y., et al. (2012). Orally Active Peptidic Bradykinin B1 Receptor Antagonists Engineered from a Cyclotide Scaffold for Inflammatory Pain Treatment. Angewandte Chemie International Edition, 51(23), 5620-5624. 1433-7851 https://hdl.handle.net/10356/98385 http://hdl.handle.net/10220/12497 10.1002/anie.201200984 en Angewandte chemie international edition © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
institution	Nanyang Technological University
building	NTU Library
country	Singapore
collection	DR-NTU
language	English
topic	DRNTU::Science::Biological sciences
spellingShingle	DRNTU::Science::Biological sciences Wong, Clarence T. T. Rowlands, Dewi K. Wong, Chi-Hang. Lo, Theodore W. C. Nguyen, Giang K. T. Li, Hoi-Yeung Tam, James P. Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment
description	Edible: By grafting natural peptide antagonists onto the cyclotide kalata B1, orally active peptides were engineered, which are potentially useful therapeutics for the treatment of inflammatory pain. For example, the entire loop 6 of kalata B1 was replaced with the peptidic bradykinin B1 receptor antagonist DALK (red in scheme) to obtain the cyclic bradykinin antagonist ckb-kal.
author2	School of Biological Sciences
author_facet	School of Biological Sciences Wong, Clarence T. T. Rowlands, Dewi K. Wong, Chi-Hang. Lo, Theodore W. C. Nguyen, Giang K. T. Li, Hoi-Yeung Tam, James P.
format	Article
author	Wong, Clarence T. T. Rowlands, Dewi K. Wong, Chi-Hang. Lo, Theodore W. C. Nguyen, Giang K. T. Li, Hoi-Yeung Tam, James P.
author_sort	Wong, Clarence T. T.
title	Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment
title_short	Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment
title_full	Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment
title_fullStr	Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment
title_full_unstemmed	Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment
title_sort	orally active peptidic bradykinin b1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment
publishDate	2013
url	https://hdl.handle.net/10356/98385 http://hdl.handle.net/10220/12497
_version_	1681048897525383168

Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment

Similar Items