Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment

• Main Authors: Wong, Clarence T. T., Rowlands, Dewi K., Wong, Chi-Hang., Lo, Theodore W. C., Nguyen, Giang K. T., Li, Hoi-Yeung, Tam, James P.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/98385; http://hdl.handle.net/10220/12497
• Institution: Nanyang Technological University

Edible: By grafting natural peptide antagonists onto the cyclotide kalata B1, orally active peptides were engineered, which are potentially useful therapeutics for the treatment of inflammatory pain. For example, the entire loop 6 of kalata B1 was replaced with the peptidic bradykinin B1 receptor an...