Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis

• Main Authors: Luo, K. Q., Park, W., Tsai, J., Liu, A. Q., Chin, Lip Ket, Je, Minkyu, Kwong, Dim Lee
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Conference or Workshop Item
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Medicine::Biomedical engineering
• Online Access: https://hdl.handle.net/10356/98436; http://hdl.handle.net/10220/12493
• Institution: Nanyang Technological University

This paper presents the formation of double-layer cellular tumor spheroid for the co-culture of hepatocyte (HepG2 cancer liver cell and LO2 normal liver cell) using alginate hydrogel. With the microfluidic chip, double-layer cellular tumor spheroid can be formed by the hydrogel droplet to mimic the...