Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis

Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis

This paper presents the formation of double-layer cellular tumor spheroid for the co-culture of hepatocyte (HepG2 cancer liver cell and LO2 normal liver cell) using alginate hydrogel. With the microfluidic chip, double-layer cellular tumor spheroid can be formed by the hydrogel droplet to mimic the...

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Bibliographic Details
Main Authors: Luo, K. Q., Park, W., Tsai, J., Liu, A. Q., Chin, Lip Ket, Je, Minkyu, Kwong, Dim Lee
Other Authors: School of Chemical and Biomedical Engineering
Format: Conference or Workshop Item
Language:English
Published: 2013
Subjects:
DRNTU::Science::Medicine::Biomedical engineering
Online Access:https://hdl.handle.net/10356/98436
http://hdl.handle.net/10220/12493
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Institution: Nanyang Technological University
Language: English
Description
Summary:This paper presents the formation of double-layer cellular tumor spheroid for the co-culture of hepatocyte (HepG2 cancer liver cell and LO2 normal liver cell) using alginate hydrogel. With the microfluidic chip, double-layer cellular tumor spheroid can be formed by the hydrogel droplet to mimic the in vivo environment in which the cancer cell is surrounded by normal cell. A microchip with concentration gradient generation and tumor spheroid trapping site is designed for anti-cancer drug analysis.

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