Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis

This paper presents the formation of double-layer cellular tumor spheroid for the co-culture of hepatocyte (HepG2 cancer liver cell and LO2 normal liver cell) using alginate hydrogel. With the microfluidic chip, double-layer cellular tumor spheroid can be formed by the hydrogel droplet to mimic the...

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Main Authors:	Luo, K. Q., Park, W., Tsai, J., Liu, A. Q., Chin, Lip Ket, Je, Minkyu, Kwong, Dim Lee
Other Authors:	School of Chemical and Biomedical Engineering
Format:	Conference or Workshop Item
Language:	English
Published:	2013
Subjects:	DRNTU::Science::Medicine::Biomedical engineering
Online Access:	https://hdl.handle.net/10356/98436 http://hdl.handle.net/10220/12493
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Institution:	Nanyang Technological University
Language:	English

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spelling	sg-ntu-dr.10356-984362020-03-07T13:24:48Z Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis Luo, K. Q. Park, W. Tsai, J. Liu, A. Q. Chin, Lip Ket Je, Minkyu Kwong, Dim Lee School of Chemical and Biomedical Engineering School of Electrical and Electronic Engineering IEEE International Conference on Micro Electro Mechanical Systems (25th : 2012 : Paris, France) DRNTU::Science::Medicine::Biomedical engineering This paper presents the formation of double-layer cellular tumor spheroid for the co-culture of hepatocyte (HepG2 cancer liver cell and LO2 normal liver cell) using alginate hydrogel. With the microfluidic chip, double-layer cellular tumor spheroid can be formed by the hydrogel droplet to mimic the in vivo environment in which the cancer cell is surrounded by normal cell. A microchip with concentration gradient generation and tumor spheroid trapping site is designed for anti-cancer drug analysis. 2013-07-29T07:50:25Z 2019-12-06T19:55:14Z 2013-07-29T07:50:25Z 2019-12-06T19:55:14Z 2012 2012 Conference Paper Chin, L. K., Luo, K. Q., Park, W., Je, M., Tsai, J., Kwong, D. L., et al. (2012). Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis. 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems (MEMS). https://hdl.handle.net/10356/98436 http://hdl.handle.net/10220/12493 10.1109/MEMSYS.2012.6170309 en © 2012 IEEE .
institution	Nanyang Technological University
building	NTU Library
country	Singapore
collection	DR-NTU
language	English
topic	DRNTU::Science::Medicine::Biomedical engineering
spellingShingle	DRNTU::Science::Medicine::Biomedical engineering Luo, K. Q. Park, W. Tsai, J. Liu, A. Q. Chin, Lip Ket Je, Minkyu Kwong, Dim Lee Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis
description	This paper presents the formation of double-layer cellular tumor spheroid for the co-culture of hepatocyte (HepG2 cancer liver cell and LO2 normal liver cell) using alginate hydrogel. With the microfluidic chip, double-layer cellular tumor spheroid can be formed by the hydrogel droplet to mimic the in vivo environment in which the cancer cell is surrounded by normal cell. A microchip with concentration gradient generation and tumor spheroid trapping site is designed for anti-cancer drug analysis.
author2	School of Chemical and Biomedical Engineering
author_facet	School of Chemical and Biomedical Engineering Luo, K. Q. Park, W. Tsai, J. Liu, A. Q. Chin, Lip Ket Je, Minkyu Kwong, Dim Lee
format	Conference or Workshop Item
author	Luo, K. Q. Park, W. Tsai, J. Liu, A. Q. Chin, Lip Ket Je, Minkyu Kwong, Dim Lee
author_sort	Luo, K. Q.
title	Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis
title_short	Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis
title_full	Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis
title_fullStr	Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis
title_full_unstemmed	Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis
title_sort	double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis
publishDate	2013
url	https://hdl.handle.net/10356/98436 http://hdl.handle.net/10220/12493
_version_	1681034174373298176

Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis

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