Mild and efficient C2-alkenylation of indoles with alkynes catalyzed by a cobalt complex

Direct alkenylation of the C2-position of indoles bearing an easily removable N-pyrimidyl group with alkynes has been achieved by using a cobalt catalyst complexed with a phosphine–pyridine bidentate ligand. This reaction has wide substrate scope and is highly efficient and stereoselective at room t...

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Main Authors:	Ding, Zhenhua, Yoshikai, Naohiko
Other Authors:	School of Physical and Mathematical Sciences
Format:	Article
Language:	English
Published:	2013
Subjects:	DRNTU::Science::Chemistry
Online Access:	https://hdl.handle.net/10356/98454 http://hdl.handle.net/10220/12470
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Institution:	Nanyang Technological University
Language:	English

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spelling	sg-ntu-dr.10356-984542020-03-07T12:34:47Z Mild and efficient C2-alkenylation of indoles with alkynes catalyzed by a cobalt complex Ding, Zhenhua Yoshikai, Naohiko School of Physical and Mathematical Sciences DRNTU::Science::Chemistry Direct alkenylation of the C2-position of indoles bearing an easily removable N-pyrimidyl group with alkynes has been achieved by using a cobalt catalyst complexed with a phosphine–pyridine bidentate ligand. This reaction has wide substrate scope and is highly efficient and stereoselective at room temperature. The alkenylated indoles serve as useful platforms for further synthetic transformations (some products of these transformations are shown in the scheme). 2013-07-29T06:55:44Z 2019-12-06T19:55:24Z 2013-07-29T06:55:44Z 2019-12-06T19:55:24Z 2012 2012 Journal Article Ding, Z., & Yoshikai, N. (2012). Mild and Efficient C2-Alkenylation of Indoles with Alkynes Catalyzed by a Cobalt Complex. Angewandte Chemie International Edition, 51(19), 4698-4701. 1433-7851 https://hdl.handle.net/10356/98454 http://hdl.handle.net/10220/12470 10.1002/anie.201200019 en Angewandte chemie international edition © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
institution	Nanyang Technological University
building	NTU Library
country	Singapore
collection	DR-NTU
language	English
topic	DRNTU::Science::Chemistry
spellingShingle	DRNTU::Science::Chemistry Ding, Zhenhua Yoshikai, Naohiko Mild and efficient C2-alkenylation of indoles with alkynes catalyzed by a cobalt complex
description	Direct alkenylation of the C2-position of indoles bearing an easily removable N-pyrimidyl group with alkynes has been achieved by using a cobalt catalyst complexed with a phosphine–pyridine bidentate ligand. This reaction has wide substrate scope and is highly efficient and stereoselective at room temperature. The alkenylated indoles serve as useful platforms for further synthetic transformations (some products of these transformations are shown in the scheme).
author2	School of Physical and Mathematical Sciences
author_facet	School of Physical and Mathematical Sciences Ding, Zhenhua Yoshikai, Naohiko
format	Article
author	Ding, Zhenhua Yoshikai, Naohiko
author_sort	Ding, Zhenhua
title	Mild and efficient C2-alkenylation of indoles with alkynes catalyzed by a cobalt complex
title_short	Mild and efficient C2-alkenylation of indoles with alkynes catalyzed by a cobalt complex
title_full	Mild and efficient C2-alkenylation of indoles with alkynes catalyzed by a cobalt complex
title_fullStr	Mild and efficient C2-alkenylation of indoles with alkynes catalyzed by a cobalt complex
title_full_unstemmed	Mild and efficient C2-alkenylation of indoles with alkynes catalyzed by a cobalt complex
title_sort	mild and efficient c2-alkenylation of indoles with alkynes catalyzed by a cobalt complex
publishDate	2013
url	https://hdl.handle.net/10356/98454 http://hdl.handle.net/10220/12470
_version_	1681047631806070784

Mild and efficient C2-alkenylation of indoles with alkynes catalyzed by a cobalt complex

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