Identification of residues involved in water versus glycerol selectivity in aquaporins by differential residue pair co-evolution

• Main Authors: Lin, Xin, Hong, Tian, Mu, Yuguang, Torres, Jaume
• Other Authors: School of Civil and Environmental Engineering
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/98837; http://hdl.handle.net/10220/12691
• Institution: Nanyang Technological University

Aquaporins (AQPs) are members of the Major Intrinsic Protein (MIP) family that can transport water or glycerol, as well as other compounds. The rationale for substrate selectivity at the structural level is still incompletely understood. The information present in multiple sequence alignments (MSAs)...