Identification of residues involved in water versus glycerol selectivity in aquaporins by differential residue pair co-evolution

• Main Authors: Lin, Xin, Hong, Tian, Mu, Yuguang, Torres, Jaume
• 其他作者: School of Civil and Environmental Engineering
• 格式: Article
• 語言: English
• 出版: 2013
• 在線閱讀: https://hdl.handle.net/10356/98837; http://hdl.handle.net/10220/12691

Aquaporins (AQPs) are members of the Major Intrinsic Protein (MIP) family that can transport water or glycerol, as well as other compounds. The rationale for substrate selectivity at the structural level is still incompletely understood. The information present in multiple sequence alignments (MSAs)...