Structure, activity and interactions of the cysteine deleted analog of tachyplesin-1 with lipopolysaccharide micelle : mechanistic insights into outer-membrane permeabilization and endotoxin neutralization

Tachyplesin-1, a disulfide stabilized β-hairpin antimicrobial peptide, can be found at the hemocytes of horse shoe crab Tachypleus tridentatus. A cysteine deleted linear analog of tachyplesin-1 or CDT (KWFRVYRGIYRRR-NH2) contains a broad spectrum of bactericidal activity with a reduced hemolytic pro...

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Bibliographic Details
Main Authors: Saravanan, Rathi, Mohanram, Harini, Joshi, Mangesh, Torres, Jaume, Ruedl, Christiane, Bhattacharjya, Surajit, Domadia, Prerna N.
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2013
Subjects:
Online Access:https://hdl.handle.net/10356/98894
http://hdl.handle.net/10220/12689
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Institution: Nanyang Technological University
Language: English

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