Interference of intrinsic curvature of DNA by DNA-intercalating agents

Interference of intrinsic curvature of DNA by DNA-intercalating agents

It has been demonstrated in our studies that the intrinsic curvature of DNA can be easily interrupted by low concentrations of chloroquine and ethidium bromide. In addition, the changes of DNA curvature caused by varying the concentration of these two DNA intercalators can be readily verified throug...

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Bibliographic Details
Main Authors: Tan, Hong Kee, Li, Dawei, Gray, Robert Kenneth, Yang, Zhaoqi, Ng, Magdeline Tao Tao, Zhang, Hao, Tan, Joel Ming Rui, Hiew, Shu Hui, Lee, Jasmine Yiqin, Li, Tianhu
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/99168
http://hdl.handle.net/10220/17249
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Institution: Nanyang Technological University
Language: English
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Summary:It has been demonstrated in our studies that the intrinsic curvature of DNA can be easily interrupted by low concentrations of chloroquine and ethidium bromide. In addition, the changes of DNA curvature caused by varying the concentration of these two DNA intercalators can be readily verified through using an atomic force microscope.

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