Intrinsic curvature in duplex DNA inhibits human Topoisomerase I

Intrinsic curvature in duplex DNA inhibits human Topoisomerase I

Human Topoisomerase I (hTopo I) have been known as a potential target for cancer therapy. A series of duplex DNA with different intrinsic curvatures have been designed as inhibitors to hTopo I. The activities of hTopo I on relaxing supercoiled plasmid pUC 19 are apparently diminished in the presence...

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Bibliographic Details
Main Authors: Yang, Zhaoqi, Li, Dawei, Guo, Juanjuan, Shao, Fangwei, Li, Tianhu
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/99011
http://hdl.handle.net/10220/12779
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Institution: Nanyang Technological University
Language: English

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https://hdl.handle.net/10356/99011
http://hdl.handle.net/10220/12779

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