Intrinsic curvature in duplex DNA inhibits human Topoisomerase I

• Main Authors: Yang, Zhaoqi, Li, Dawei, Guo, Juanjuan, Shao, Fangwei, Li, Tianhu
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/99011; http://hdl.handle.net/10220/12779
• Institution: Nanyang Technological University

Human Topoisomerase I (hTopo I) have been known as a potential target for cancer therapy. A series of duplex DNA with different intrinsic curvatures have been designed as inhibitors to hTopo I. The activities of hTopo I on relaxing supercoiled plasmid pUC 19 are apparently diminished in the presence...