Development of HIV-1 fusion inhibitors targeting gp41
The HIV-1 envelope protein glycoprotein 41 (gp41) is crucial in the HIV-1 infection process, therefore gp41 has emerged as an attractive target for drug design against AIDS. During the past few decades, tremendous efforts have been made on developing inhibitors that can prevent the HIV-1 entry proce...
Saved in:
| Main Authors: | , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2014
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/99957 http://hdl.handle.net/10220/19663 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Nanyang Technological University |
| Language: | English |
| id |
sg-ntu-dr.10356-99957 |
|---|---|
| record_format |
dspace |
| spelling |
sg-ntu-dr.10356-999572020-03-07T12:34:50Z Development of HIV-1 fusion inhibitors targeting gp41 Lu, K. Asyifah, M. R. Shao, F. Zhang, D. School of Physical and Mathematical Sciences DRNTU::Science::Medicine::Biomedical engineering The HIV-1 envelope protein glycoprotein 41 (gp41) is crucial in the HIV-1 infection process, therefore gp41 has emerged as an attractive target for drug design against AIDS. During the past few decades, tremendous efforts have been made on developing inhibitors that can prevent the HIV-1 entry process via suppressing functional gp41. In this review, the development of HIV-1 fusion inhibitors targeting gp41 including peptide inhibitors, small molecule inhibitors, vaccines and neutralized antibodies will be discussed. 2014-06-11T04:56:25Z 2019-12-06T20:14:01Z 2014-06-11T04:56:25Z 2019-12-06T20:14:01Z 2014 2014 Journal Article Lu, K., Asyifah, M., Shao, F., & Zhang, D. (2014). Development of HIV-1 Fusion Inhibitors Targeting gp41. Current Medicinal Chemistry, 21(17), 1976-1996. 0929-8673 https://hdl.handle.net/10356/99957 http://hdl.handle.net/10220/19663 10.2174/0929867321666131218094559 en Current medicinal chemistry © 2014 Bentham Science Publishers. |
| institution |
Nanyang Technological University |
| building |
NTU Library |
| country |
Singapore |
| collection |
DR-NTU |
| language |
English |
| topic |
DRNTU::Science::Medicine::Biomedical engineering |
| spellingShingle |
DRNTU::Science::Medicine::Biomedical engineering Lu, K. Asyifah, M. R. Shao, F. Zhang, D. Development of HIV-1 fusion inhibitors targeting gp41 |
| description |
The HIV-1 envelope protein glycoprotein 41 (gp41) is crucial in the HIV-1 infection process, therefore gp41 has emerged as an attractive target for drug design against AIDS. During the past few decades, tremendous efforts have been made on developing inhibitors that can prevent the HIV-1 entry process via suppressing functional gp41. In this review, the development of HIV-1 fusion inhibitors targeting gp41 including peptide inhibitors, small molecule inhibitors, vaccines and neutralized antibodies will be discussed. |
| author2 |
School of Physical and Mathematical Sciences |
| author_facet |
School of Physical and Mathematical Sciences Lu, K. Asyifah, M. R. Shao, F. Zhang, D. |
| format |
Article |
| author |
Lu, K. Asyifah, M. R. Shao, F. Zhang, D. |
| author_sort |
Lu, K. |
| title |
Development of HIV-1 fusion inhibitors targeting gp41 |
| title_short |
Development of HIV-1 fusion inhibitors targeting gp41 |
| title_full |
Development of HIV-1 fusion inhibitors targeting gp41 |
| title_fullStr |
Development of HIV-1 fusion inhibitors targeting gp41 |
| title_full_unstemmed |
Development of HIV-1 fusion inhibitors targeting gp41 |
| title_sort |
development of hiv-1 fusion inhibitors targeting gp41 |
| publishDate |
2014 |
| url |
https://hdl.handle.net/10356/99957 http://hdl.handle.net/10220/19663 |
| _version_ |
1681036388824252416 |