Does the combination of optimal substitutions at the C 2-, N 5- and N 8-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A 3 adenosine receptors?

Does the combination of optimal substitutions at the C 2-, N 5- and N 8-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A 3 adenosine receptors?

10.1016/j.bmc.2011.08.026

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Bibliographic Details
Main Authors: Cheong, S.L., Dolzhenko, A.V., Paoletta, S., Lee, E.P.R., Kachler, S., Federico, S., Klotz, K.-N., Spalluto, G., Moro, S., Pastorin, G.
Other Authors: PHARMACY
Format: Article
Published: 2014
Subjects:
2-Phenyl-pyrazolo-triazolo-pyrimidines
Affinity
Human A 3 adenosine receptor antagonists
Selectivity
Structure-affinity relationship
Online Access:http://scholarbank.nus.edu.sg/handle/10635/105850
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Institution: National University of Singapore
Description
Summary:10.1016/j.bmc.2011.08.026

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