Exploring aigialomycin D and its analogues as protein kinase inhibitors for cancer targets

Exploring aigialomycin D and its analogues as protein kinase inhibitors for cancer targets

10.1021/ml200067t

Saved in:

Bibliographic Details
Main Authors:	Xu, J., Chen, A., Go, M.-L., Nacro, K., Liu, B., Chai, C.L.L.
Other Authors:	PHARMACY
Format:	Article
Published:	2014
Subjects:	Aigialomycin D CDK2 kinase inhibitor MNK resorcylic acid lactone
Online Access:	http://scholarbank.nus.edu.sg/handle/10635/105945
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	National University of Singapore

Similar Items

SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF RESORCYLIC ACID LACTONES AND DERIVATIVES AS PROTEIN KINASE INHIBITORS TARGETING TO CANCERS
by: XU JIN
Published: (2015)

Rational design of resorcylic acid lactone analogues as covalent MNK1/2 kinase inhibitors by tuning the reactivity of an enamide Michael acceptor
by: Xu, J., et al.
Published: (2014)

ADDICTION OF SOFT-TISSUE SARCOMA CELLS TO MNK AND EIF4E
by: KE XINYU
Published: (2021)

ENGINEERING NOVEL COMPOUNDS AS SPHINGOSINE KINASE INHIBITORS
by: WONG LINGKAI
Published: (2011)

Dual targeting of glioblastoma multiforme with a proteasome inhibitor (Velcade) and a phosphatidylinositol 3-kinase inhibitor (ZSTK474)
by: Lin, L., et al.
Published: (2016)

EXPLORING THE ROLE OF PHARMACOKINETIC ALTERATIONS IN TYROSINE KINASE INHIBITORS (TKIS)-ASSOCIATED TOXICITIES
by: TEO YI LING
Published: (2015)

Fusaric acid and analogues as Gram-negative bacterial quorum sensing inhibitors
by: Tung, Truong Thanh, et al.
Published: (2017)

Tannic acid, a potent inhibitor of epidermal growth factor receptor tyrosine kinase
by: Yang, E.B., et al.
Published: (2014)

MECHANISMS OF HYPOXIA-INDUCED GROWTH AND TYROSINE KINASE INHIBITOR RESISTANCE IN CHRONIC MYELOID LEUKEMIA
by: MANJERI ADITI SUBRAMANIAM
Published: (2019)

Identification and characterization of protein kinase CK2 as a novel interacting protein of neuronal CDK5 kinase and its functional role in microtubule dynamics
by: LIM CHEE BENG
Published: (2010)

Rational drug combination design in patient-derived avatars reveals effective inhibition of hepatocellular carcinoma with proteasome and CDK inhibitors
by: Lim, Jhin Jieh, et al.
Published: (2023)

Risk of tyrosine kinase inhibitors-induced hepatotoxicity in cancer patients: A meta-analysis
by: Teo, Y.L., et al.
Published: (2014)

Functional Effects of a Novel BIM Deletion Polymorphism in Mediating Resistance to Tyrosine Kinase Inhibitors in Cancer
by: JUAN WEN CHUN
Published: (2014)

Development of phosphodiesterase–protein-kinase complexes as novel targets for discovery of inhibitors with enhanced specificity
by: Tulsian, Nikhil K., et al.
Published: (2022)

Design and synthesis of receptor tyrosine kinase inhibitors for anticancer treatment
by: Chawannuch Mudjupa
Published: (2023)

Construction of Fused Pyrrolidines and β-Lactones by Carbene-Catalyzed C−N, C−C, and C−O Bond Formations
by: Wu, Xingxing, et al.
Published: (2017)

Preclinical characteristics of the irreversible pan-HER kinase inhibitor neratinib compared with lapatinib : implications for the treatment of HER2-positive and HER2-mutated breast cancer
by: Collins, Denis M., et al.
Published: (2020)

An in silico approach for the discovery of CDK5/p25 interaction inhibitors
by: Zhang, B., et al.
Published: (2014)

ABT-869, a multi-targeted tyrosine kinase inhibitor, in combination with rapamycin is effective for subcutaneous hepatocellular carcinoma xenograft
by: Jasinghe, V.J., et al.
Published: (2011)

Exploration of 1-(3-chloro-4-(4-oxo-4H-chromen-2-yl)phenyl)-3-phenylurea derivatives as selective dual inhibitors of Raf1 and JNK1 kinases for anti-tumor treatment
by: Jin, F., et al.
Published: (2014)

Design, synthesis and biological studies of coumarin-based probes and tetrahydrolipstatin analogs
by: NGAI MUN HONG
Published: (2011)

Preclinical characteristics of the irreversible pan- her kinase inhibitor neratinib compared with lapatinib: Implications for the treatment of HER2- positive and HER2-mutated breast cancer
by: Collins, D.M., et al.
Published: (2021)

Studies of regulatory and functional properties of the neuronal CdK5 Kinase using functional proteomics
by: QU DIANBO
Published: (2013)

How well does the MESTT correlate with CTCAE scale for the grading of dermatological toxicities associated with oral tyrosine kinase inhibitors?
by: Chan, A., et al.
Published: (2014)

Virtual screening of selective multitarget kinase inhibitors by combinatorial support vector machines
by: Ma, X.H., et al.
Published: (2014)

A new synthesis of [alpha], [beta]-unsaturated [gamma]- and [alpha]-lactones via intramolecular acylation of [alpha]-sulfinyl carbanion
by: Prapanpong Jarupan
Published: (2023)

Developing FGFR4 inhibitors as potential anti-cancer agents via in silico design, supported by in vitro and cell-based testing
by: Ho, H.K., et al.
Published: (2014)

Potential roles for the PIM1 kinase in human cancer - A molecular and therapeutic appraisal
by: Shah, N., et al.
Published: (2012)

The protein kinase CK2 catalytic domain from Plasmodium falciparum: Crystal structure, tyrosine kinase activity and inhibition
by: Ruiz-Carrillo, D, et al.
Published: (2020)

UNBIASED PHOSPHOPROTEOMICS ANALYSIS UNVEILS MODULATION OF INSULIN SIGNALING BY EXTRAMITOTIC CDK1 KINASE ACTIVITY IN HUMAN MYOTUBES
by: LIEW WEI LIN
Published: (2024)

The gene encoding the p53-regulated inhibitor of CDKs (PIC1) is not expressed in the Molt-4 leukemia cell line with p53 truncated at the carboxyl terminus, and harbors a nucleotide substitution at codon 31 in several other cancer cell lines
by: Chow, V.T.K., et al.
Published: (2016)

Synthesis of cyclic di-nucleotidic acids as potential inhibitors targeting diguanylate cyclase
by: Ching, S.M., et al.
Published: (2014)

Discovery of benzimidazole derivatives as novel multi-target EGFR, VEGFR-2 and PDGFR kinase inhibitors
by: Li, Y., et al.
Published: (2014)

Targeting ROS1 with anaplastic lymphoma kinase inhibitors: A promising therapeutic strategy for a newly defined molecular subset of non-small-cell lung cancer
by: Chin, L.P., et al.
Published: (2014)

NHC-catalyzed cascade reaction between β-methyl enals and dienones for quick construction of complex multicyclic lactones
by: Sun, Jun, et al.
Published: (2021)

High performance computational virtual screening tools: development and application to the discovery of kinase inhibitors
by: MA XIAOHUA
Published: (2011)

c-Src protein kinase inhibitors block assembly and maturation of dengue virus
by: Chu, JJH, et al.
Published: (2020)

Targeting microtubules sensitizes drug resistant lung cancer cells to lysosomal pathway inhibitors
by: Chin, T.-M., et al.
Published: (2021)

Exploration of (S)-3-aminopyrrolidine as a potentially interesting scaffold for discovery of novel Abl and PI3K dual inhibitors
by: Zhang, C., et al.
Published: (2014)

Exploration of N-(2-aminoethyl)piperidine-4-carboxamide as a potential scaffold for development of VEGFR-2, ERK-2 and Abl-1 multikinase inhibitor
by: Jin, F., et al.
Published: (2014)