Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: Conformational selection highlights a new concept in allosteric inhibitor design
10.1074/mcp.M110.004390
Saved in:
Main Authors: | Badireddy, S., Yunfeng, G., Ritchie, M., Akamine, P., Wu, J., Kim, C.W., Taylor, S.S., Qingsong, L., Swaminathan, K., Anand, G.S. |
---|---|
Other Authors: | MECHANOBIOLOGY INSTITUTE |
Format: | Article |
Published: |
2014
|
Online Access: | http://scholarbank.nus.edu.sg/handle/10635/113125 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | National University of Singapore |
Similar Items
-
Cyclic AMP-induced conformational changes in mycobacterial protein acetyltransferases
by: Nambi, S., et al.
Published: (2014) -
Cyclic AMP- and (Rp)-cAMPS-induced conformational changes in a complex of the catalytic and regulatory (RIα) subunits of cyclic AMP-dependent protein kinase
by: Anand, G.S., et al.
Published: (2014) -
Cooperativity and allostery in cAMP-dependent activation of Protein Kinase A: Monitoring conformations of intermediates by amide hydrogen/deuterium exchange
by: Moorthy, B.S., et al.
Published: (2014) -
Coherent conformational degrees of freedom as a structural basis for allosteric communication
by: Mitternacht S., et al.
Published: (2019) -
Conformational landscape of the epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket
by: Kannan, S., et al.
Published: (2022)