Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases

Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases

10.1002/anie.201107833

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Bibliographic Details
Main Authors: Woon, E.C.Y., Tumber, A., Kawamura, A., Hillringhaus, L., Ge, W., Rose, N.R., Ma, J.H.Y., Chan, M.C., Walport, L.J., Che, K.H., Ng, S.S., Marsden, B.D., Oppermann, U., McDonough, M.A., Schofield, C.J.
Other Authors: PHARMACY
Format: Article
Published: 2016
Subjects:
2-oxoglutarate
epigenetics
histone lysine demethylases
oxygenases
thiol-ene reaction
Online Access:http://scholarbank.nus.edu.sg/handle/10635/125025
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Institution: National University of Singapore
Description
Summary:10.1002/anie.201107833

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