Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases

• Main Authors: Woon, E.C.Y., Tumber, A., Kawamura, A., Hillringhaus, L., Ge, W., Rose, N.R., Ma, J.H.Y., Chan, M.C., Walport, L.J., Che, K.H., Ng, S.S., Marsden, B.D., Oppermann, U., McDonough, M.A., Schofield, C.J.
• Other Authors: PHARMACY
• Format: Article
• Published: 2016
• Subjects: 2-oxoglutarate; epigenetics; histone lysine demethylases; oxygenases; thiol-ene reaction
• Online Access: http://scholarbank.nus.edu.sg/handle/10635/125025
• Institution: National University of Singapore

10.1002/anie.201107833