Drosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects

• Main Authors: Chang J.-C., Morton D.B.
• Other Authors: PHYSIOLOGY
• Format: Article
• Published: 2019
• Subjects: mutant protein; proteasome; TAR DNA binding protein; DNA binding protein; TDP-43 protein, human; adult; age; aged; animal experiment; animal tissue; Article; behavior disorder; controlled study; cytoplasm; developmental disorder; Drosophila; embryo; female; gene mutation; genetic transcription; genome; heredity; hTDP 43 gene; immunoprecipitation; longevity; male; nerve cell; nonhuman; protein function; protein localization; protein phosphorylation; ubiquitination; wild type; aging; animal; cytology; Drosophila melanogaster; genetics; growth, development and aging; human; metabolism; mutation; phosphorylation; physiology; protein processing; signal transduction; taxis response; transgene; transgenic animal; Aging; Animals; Animals, Genetically Modified; DNA-Binding Proteins; Female; Humans; Longevity; Male; Mutation; Neurons; Phosphorylation; Protein Processing, Post-Translational; Signal Transduction; Taxis Response; Transgenes; Ubiquitination
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161186
• Institution: National University of Singapore

10.1371/journal.pone.0180828