Drosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects

10.1371/journal.pone.0180828

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Main Authors:	Chang J.-C., Morton D.B.
Other Authors:	PHYSIOLOGY
Format:	Article
Published:	2019
Subjects:	mutant protein proteasome TAR DNA binding protein DNA binding protein TDP-43 protein, human adult age aged animal experiment animal tissue Article behavior disorder controlled study cytoplasm developmental disorder Drosophila embryo female gene mutation genetic transcription genome heredity hTDP 43 gene immunoprecipitation longevity male nerve cell nonhuman protein function protein localization protein phosphorylation ubiquitination wild type aging animal cytology Drosophila melanogaster genetics growth, development and aging human metabolism mutation phosphorylation physiology protein processing signal transduction taxis response transgene transgenic animal Aging Animals Animals, Genetically Modified DNA-Binding Proteins Female Humans Longevity Male Mutation Neurons Phosphorylation Protein Processing, Post-Translational Signal Transduction Taxis Response Transgenes Ubiquitination
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161186
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1611862024-04-04T01:11:22Z Drosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects Chang J.-C. Morton D.B. PHYSIOLOGY mutant protein proteasome TAR DNA binding protein DNA binding protein TDP-43 protein, human adult age aged animal experiment animal tissue Article behavior disorder controlled study cytoplasm developmental disorder Drosophila embryo female gene mutation genetic transcription genome heredity hTDP 43 gene immunoprecipitation longevity male nerve cell nonhuman protein function protein localization protein phosphorylation ubiquitination wild type aging animal cytology Drosophila melanogaster genetics growth, development and aging human longevity metabolism mutation phosphorylation physiology protein processing signal transduction taxis response transgene transgenic animal ubiquitination Aging Animals Animals, Genetically Modified DNA-Binding Proteins Drosophila melanogaster Female Humans Longevity Male Mutation Neurons Phosphorylation Protein Processing, Post-Translational Signal Transduction Taxis Response Transgenes Ubiquitination 10.1371/journal.pone.0180828 PLoS ONE 12 7 e0180828 2019-11-01T07:51:32Z 2019-11-01T07:51:32Z 2017 Article Chang J.-C., Morton D.B. (2017). Drosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects. PLoS ONE 12 (7) : e0180828. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0180828 19326203 https://scholarbank.nus.edu.sg/handle/10635/161186 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	mutant protein proteasome TAR DNA binding protein DNA binding protein TDP-43 protein, human adult age aged animal experiment animal tissue Article behavior disorder controlled study cytoplasm developmental disorder Drosophila embryo female gene mutation genetic transcription genome heredity hTDP 43 gene immunoprecipitation longevity male nerve cell nonhuman protein function protein localization protein phosphorylation ubiquitination wild type aging animal cytology Drosophila melanogaster genetics growth, development and aging human longevity metabolism mutation phosphorylation physiology protein processing signal transduction taxis response transgene transgenic animal ubiquitination Aging Animals Animals, Genetically Modified DNA-Binding Proteins Drosophila melanogaster Female Humans Longevity Male Mutation Neurons Phosphorylation Protein Processing, Post-Translational Signal Transduction Taxis Response Transgenes Ubiquitination
spellingShingle	mutant protein proteasome TAR DNA binding protein DNA binding protein TDP-43 protein, human adult age aged animal experiment animal tissue Article behavior disorder controlled study cytoplasm developmental disorder Drosophila embryo female gene mutation genetic transcription genome heredity hTDP 43 gene immunoprecipitation longevity male nerve cell nonhuman protein function protein localization protein phosphorylation ubiquitination wild type aging animal cytology Drosophila melanogaster genetics growth, development and aging human longevity metabolism mutation phosphorylation physiology protein processing signal transduction taxis response transgene transgenic animal ubiquitination Aging Animals Animals, Genetically Modified DNA-Binding Proteins Drosophila melanogaster Female Humans Longevity Male Mutation Neurons Phosphorylation Protein Processing, Post-Translational Signal Transduction Taxis Response Transgenes Ubiquitination Chang J.-C. Morton D.B. Drosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects
description	10.1371/journal.pone.0180828
author2	PHYSIOLOGY
author_facet	PHYSIOLOGY Chang J.-C. Morton D.B.
format	Article
author	Chang J.-C. Morton D.B.
author_sort	Chang J.-C.
title	Drosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects
title_short	Drosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects
title_full	Drosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects
title_fullStr	Drosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects
title_full_unstemmed	Drosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects
title_sort	drosophila lines with mutant and wild type human tdp-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161186
_version_	1795374096138108928

Drosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects

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