Drosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects

Drosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects

10.1371/journal.pone.0180828

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Bibliographic Details
Main Authors:	Chang J.-C., Morton D.B.
Other Authors:	PHYSIOLOGY
Format:	Article
Published:	2019
Subjects:	mutant protein proteasome TAR DNA binding protein DNA binding protein TDP-43 protein, human adult age aged animal experiment animal tissue Article behavior disorder controlled study cytoplasm developmental disorder Drosophila embryo female gene mutation genetic transcription genome heredity hTDP 43 gene immunoprecipitation longevity male nerve cell nonhuman protein function protein localization protein phosphorylation ubiquitination wild type aging animal cytology Drosophila melanogaster genetics growth, development and aging human metabolism mutation phosphorylation physiology protein processing signal transduction taxis response transgene transgenic animal Aging Animals Animals, Genetically Modified DNA-Binding Proteins Female Humans Longevity Male Mutation Neurons Phosphorylation Protein Processing, Post-Translational Signal Transduction Taxis Response Transgenes Ubiquitination
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161186
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Institution:	National University of Singapore

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