Action of YM155 on clear cell renal cell carcinoma does not depend on surviving expression levels

Action of YM155 on clear cell renal cell carcinoma does not depend on surviving expression levels

10.1371/journal.pone.0178168

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Bibliographic Details
Main Authors:	Sim M.Y., Huynh H., Go M.L., Yuen J.S.P.
Other Authors:	PHARMACOLOGY
Format:	Article
Published:	2019
Subjects:	inhibitor of differentiation 1 messenger RNA sepantronium bromide sorafenib survivin transcription factor FKHR von Hippel Lindau protein antineoplastic agent BIRC5 protein, human carbanilamide derivative CYLD protein, human drug combination FOXO1 protein, human ID1 protein, human imidazole derivative inhibitor of apoptosis protein naphthoquinone nicotinamide tumor suppressor protein VHL protein, human animal experiment animal model animal tissue Article BIRC5 gene cancer inhibition cell viability controlled study CYLD gene drug dose comparison drug potentiation FOXO1 gene gene gene expression human human cell ID1 gene in vivo study kidney carcinoma male microarray analysis mouse nonhuman protein expression real time polymerase chain reaction renal cell carcinoma cell line transcriptomics tumor regression tumor xenograft Western blotting analogs and derivatives animal antagonists and inhibitors Carcinoma, Renal Cell cell survival dose response drug effects drug screening gene expression regulation genetics Kidney Neoplasms metabolism pathology primary cell culture SCID mouse signal transduction tumor cell line Animals Antineoplastic Agents Cell Line, Tumor Cell Survival Dose-Response Relationship, Drug Drug Combinations Forkhead Box Protein O1 Gene Expression Regulation, Neoplastic Humans Imidazoles Inhibitor of Apoptosis Proteins Inhibitor of Differentiation Protein 1 Male Mice Mice, SCID Naphthoquinones Niacinamide Phenylurea Compounds Primary Cell Culture Signal Transduction Tumor Suppressor Proteins Von Hippel-Lindau Tumor Suppressor Protein Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161190
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Institution:	National University of Singapore

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Summary:	10.1371/journal.pone.0178168