Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib
10.1371/journal.pone.0195956
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sg-nus-scholar.10635-1612332024-04-24T05:53:59Z Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib Ladds M.J.G.W. Pastor-Fernández A. Popova G. van Leeuwen I.M.M. Eng K.E. Drummond C.J. Johansson L. Svensson R. Westwood N.J. McCarthy A.R. Tholander F. Popa M. Lane D.P. McCormack E. McInerney G.M. Bhatia R. Laín S. MEDICINE antineoplastic agent B Raf kinase chloroquine protein p53 sirtuin 1 tenovin tenovin 1 tenovin 33 tenovin 39 tenovin 39 oh tenovin 50 tenovin 50 oh tenovin 6 tenovin D1 tenovin D3 tertiary amine unclassified drug vemurafenib antineoplastic agent B Raf kinase benzamide derivative BRAF protein, human indole derivative protein p53 sirtuin sulfonamide tenovin-6 TP53 protein, human vemurafenib Article autophagy cell death cell survival drug mechanism G1 phase cell cycle checkpoint human human cell melanoma cell autophagy cell proliferation chemical structure chemistry drug effect drug potentiation drug resistance gene expression regulation genetics melanoma mutation tumor cell line Antineoplastic Agents Autophagy Benzamides Cell Line, Tumor Cell Proliferation Cell Survival Drug Resistance, Neoplasm Drug Synergism Gene Expression Regulation, Neoplastic Humans Indoles Melanoma Molecular Structure Mutation Proto-Oncogene Proteins B-raf Sirtuins Sulfonamides Tumor Suppressor Protein p53 10.1371/journal.pone.0195956 PLoS ONE 13 4 e0195956 2019-11-01T08:16:15Z 2019-11-01T08:16:15Z 2018 Article Ladds M.J.G.W., Pastor-Fernández A., Popova G., van Leeuwen I.M.M., Eng K.E., Drummond C.J., Johansson L., Svensson R., Westwood N.J., McCarthy A.R., Tholander F., Popa M., Lane D.P., McCormack E., McInerney G.M., Bhatia R., Laín S. (2018). Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib. PLoS ONE 13 (4) : e0195956. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0195956 19326203 https://scholarbank.nus.edu.sg/handle/10635/161233 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101 |
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antineoplastic agent B Raf kinase chloroquine protein p53 sirtuin 1 tenovin tenovin 1 tenovin 33 tenovin 39 tenovin 39 oh tenovin 50 tenovin 50 oh tenovin 6 tenovin D1 tenovin D3 tertiary amine unclassified drug vemurafenib antineoplastic agent B Raf kinase benzamide derivative BRAF protein, human indole derivative protein p53 sirtuin sulfonamide tenovin-6 TP53 protein, human vemurafenib Article autophagy cell death cell survival drug mechanism G1 phase cell cycle checkpoint human human cell melanoma cell autophagy cell proliferation chemical structure chemistry drug effect drug potentiation drug resistance gene expression regulation genetics melanoma mutation tumor cell line Antineoplastic Agents Autophagy Benzamides Cell Line, Tumor Cell Proliferation Cell Survival Drug Resistance, Neoplasm Drug Synergism Gene Expression Regulation, Neoplastic Humans Indoles Melanoma Molecular Structure Mutation Proto-Oncogene Proteins B-raf Sirtuins Sulfonamides Tumor Suppressor Protein p53 |
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antineoplastic agent B Raf kinase chloroquine protein p53 sirtuin 1 tenovin tenovin 1 tenovin 33 tenovin 39 tenovin 39 oh tenovin 50 tenovin 50 oh tenovin 6 tenovin D1 tenovin D3 tertiary amine unclassified drug vemurafenib antineoplastic agent B Raf kinase benzamide derivative BRAF protein, human indole derivative protein p53 sirtuin sulfonamide tenovin-6 TP53 protein, human vemurafenib Article autophagy cell death cell survival drug mechanism G1 phase cell cycle checkpoint human human cell melanoma cell autophagy cell proliferation chemical structure chemistry drug effect drug potentiation drug resistance gene expression regulation genetics melanoma mutation tumor cell line Antineoplastic Agents Autophagy Benzamides Cell Line, Tumor Cell Proliferation Cell Survival Drug Resistance, Neoplasm Drug Synergism Gene Expression Regulation, Neoplastic Humans Indoles Melanoma Molecular Structure Mutation Proto-Oncogene Proteins B-raf Sirtuins Sulfonamides Tumor Suppressor Protein p53 Ladds M.J.G.W. Pastor-Fernández A. Popova G. van Leeuwen I.M.M. Eng K.E. Drummond C.J. Johansson L. Svensson R. Westwood N.J. McCarthy A.R. Tholander F. Popa M. Lane D.P. McCormack E. McInerney G.M. Bhatia R. Laín S. Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib |
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10.1371/journal.pone.0195956 |
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MEDICINE |
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MEDICINE Ladds M.J.G.W. Pastor-Fernández A. Popova G. van Leeuwen I.M.M. Eng K.E. Drummond C.J. Johansson L. Svensson R. Westwood N.J. McCarthy A.R. Tholander F. Popa M. Lane D.P. McCormack E. McInerney G.M. Bhatia R. Laín S. |
format |
Article |
author |
Ladds M.J.G.W. Pastor-Fernández A. Popova G. van Leeuwen I.M.M. Eng K.E. Drummond C.J. Johansson L. Svensson R. Westwood N.J. McCarthy A.R. Tholander F. Popa M. Lane D.P. McCormack E. McInerney G.M. Bhatia R. Laín S. |
author_sort |
Ladds M.J.G.W. |
title |
Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib |
title_short |
Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib |
title_full |
Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib |
title_fullStr |
Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib |
title_full_unstemmed |
Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib |
title_sort |
autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of b-raf mutant tumour cells that survive vemurafenib |
publishDate |
2019 |
url |
https://scholarbank.nus.edu.sg/handle/10635/161233 |
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1800913784570642432 |