Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage

10.1371/journal.pone.0093564

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Main Authors:	Dietz J.A., Maes M.E., Huang S., Yandell B.S., Schlamp C.L., Montgomery A.D., Allingham R.R., Hauser M.A., Nickells R.W.
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	2019
Subjects:	serine staurosporine threonine DNA serine protease inhibitor Kazal-type 2, mouse serine proteinase inhibitor adult aging allele amino acid substitution animal cell animal experiment animal model animal tissue apoptosis article BALB cBy mouse cell death chromosome 5 congenic strain controlled study DBA 2 mouse female gene gene deletion gene expression gene overexpression genetic variability glaucoma intron male mouse nerve crush nonhuman optic nerve lesion quantitative trait locus quantitative trait locus mapping retina ganglion cell retinal ganglion cell susceptible 1 single nucleotide polymorphism spink2 gene tissue culture animal Bagg albino mouse cytology DBA mouse metabolism molecular genetics nucleotide sequence optic nerve pathology physiology Animals Apoptosis Base Sequence Mice Mice, Inbred BALB C Mice, Inbred DBA Molecular Sequence Data Optic Nerve Polymorphism, Single Nucleotide Quantitative Trait Loci Retinal Ganglion Cells Serpins
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161420
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1614202023-10-31T21:03:51Z Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage Dietz J.A. Maes M.E. Huang S. Yandell B.S. Schlamp C.L. Montgomery A.D. Allingham R.R. Hauser M.A. Nickells R.W. DUKE-NUS MEDICAL SCHOOL serine staurosporine threonine DNA serine protease inhibitor Kazal-type 2, mouse serine proteinase inhibitor adult aging allele amino acid substitution animal cell animal experiment animal model animal tissue apoptosis article BALB cBy mouse cell death chromosome 5 congenic strain controlled study DBA 2 mouse female gene gene deletion gene expression gene overexpression genetic variability glaucoma intron male mouse nerve crush nonhuman optic nerve lesion quantitative trait locus quantitative trait locus mapping retina ganglion cell retinal ganglion cell susceptible 1 single nucleotide polymorphism spink2 gene tissue culture animal apoptosis Bagg albino mouse cytology DBA mouse metabolism molecular genetics nucleotide sequence optic nerve pathology physiology retina ganglion cell Animals Apoptosis Base Sequence DNA Mice Mice, Inbred BALB C Mice, Inbred DBA Molecular Sequence Data Optic Nerve Polymorphism, Single Nucleotide Quantitative Trait Loci Retinal Ganglion Cells Serpins 10.1371/journal.pone.0093564 PLoS ONE 9 4 e93564 2019-11-05T00:38:42Z 2019-11-05T00:38:42Z 2014 Article Dietz J.A., Maes M.E., Huang S., Yandell B.S., Schlamp C.L., Montgomery A.D., Allingham R.R., Hauser M.A., Nickells R.W. (2014). Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage. PLoS ONE 9 (4) : e93564. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0093564 1932-6203 https://scholarbank.nus.edu.sg/handle/10635/161420 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	serine staurosporine threonine DNA serine protease inhibitor Kazal-type 2, mouse serine proteinase inhibitor adult aging allele amino acid substitution animal cell animal experiment animal model animal tissue apoptosis article BALB cBy mouse cell death chromosome 5 congenic strain controlled study DBA 2 mouse female gene gene deletion gene expression gene overexpression genetic variability glaucoma intron male mouse nerve crush nonhuman optic nerve lesion quantitative trait locus quantitative trait locus mapping retina ganglion cell retinal ganglion cell susceptible 1 single nucleotide polymorphism spink2 gene tissue culture animal apoptosis Bagg albino mouse cytology DBA mouse metabolism molecular genetics nucleotide sequence optic nerve pathology physiology retina ganglion cell Animals Apoptosis Base Sequence DNA Mice Mice, Inbred BALB C Mice, Inbred DBA Molecular Sequence Data Optic Nerve Polymorphism, Single Nucleotide Quantitative Trait Loci Retinal Ganglion Cells Serpins
spellingShingle	serine staurosporine threonine DNA serine protease inhibitor Kazal-type 2, mouse serine proteinase inhibitor adult aging allele amino acid substitution animal cell animal experiment animal model animal tissue apoptosis article BALB cBy mouse cell death chromosome 5 congenic strain controlled study DBA 2 mouse female gene gene deletion gene expression gene overexpression genetic variability glaucoma intron male mouse nerve crush nonhuman optic nerve lesion quantitative trait locus quantitative trait locus mapping retina ganglion cell retinal ganglion cell susceptible 1 single nucleotide polymorphism spink2 gene tissue culture animal apoptosis Bagg albino mouse cytology DBA mouse metabolism molecular genetics nucleotide sequence optic nerve pathology physiology retina ganglion cell Animals Apoptosis Base Sequence DNA Mice Mice, Inbred BALB C Mice, Inbred DBA Molecular Sequence Data Optic Nerve Polymorphism, Single Nucleotide Quantitative Trait Loci Retinal Ganglion Cells Serpins Dietz J.A. Maes M.E. Huang S. Yandell B.S. Schlamp C.L. Montgomery A.D. Allingham R.R. Hauser M.A. Nickells R.W. Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage
description	10.1371/journal.pone.0093564
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Dietz J.A. Maes M.E. Huang S. Yandell B.S. Schlamp C.L. Montgomery A.D. Allingham R.R. Hauser M.A. Nickells R.W.
format	Article
author	Dietz J.A. Maes M.E. Huang S. Yandell B.S. Schlamp C.L. Montgomery A.D. Allingham R.R. Hauser M.A. Nickells R.W.
author_sort	Dietz J.A.
title	Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage
title_short	Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage
title_full	Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage
title_fullStr	Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage
title_full_unstemmed	Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage
title_sort	spink2 modulates apoptotic susceptibility and is a candidate gene in the rgcs1 qtl that affects retinal ganglion cell death after optic nerve damage
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161420
_version_	1781791756715556864

Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage

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