Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage

• Main Authors: Dietz J.A., Maes M.E., Huang S., Yandell B.S., Schlamp C.L., Montgomery A.D., Allingham R.R., Hauser M.A., Nickells R.W.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: serine; staurosporine; threonine; DNA; serine protease inhibitor Kazal-type 2, mouse; serine proteinase inhibitor; adult; aging; allele; amino acid substitution; animal cell; animal experiment; animal model; animal tissue; apoptosis; article; BALB cBy mouse; cell death; chromosome 5; congenic strain; controlled study; DBA 2 mouse; female; gene; gene deletion; gene expression; gene overexpression; genetic variability; glaucoma; intron; male; mouse; nerve crush; nonhuman; optic nerve lesion; quantitative trait locus; quantitative trait locus mapping; retina ganglion cell; retinal ganglion cell susceptible 1; single nucleotide polymorphism; spink2 gene; tissue culture; animal; Bagg albino mouse; cytology; DBA mouse; metabolism; molecular genetics; nucleotide sequence; optic nerve; pathology; physiology; Animals; Apoptosis; Base Sequence; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Molecular Sequence Data; Optic Nerve; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Retinal Ganglion Cells; Serpins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161420
• Institution: National University of Singapore

10.1371/journal.pone.0093564