Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma

Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma

10.1371/journal.pgen.1007145

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Main Authors:	King R., Struebing F.L., Li Y., Wang J., Koch A.A., Cooke Bailey J.N., Gharahkhani P., MacGregor S., Allingham R.R., Hauser M.A., Wiggs J.L., Geisert E.E., Brilliant M., Budenz D., Bailey J.C., Fingert J., Gaasterland D., Gaasterland T., Haines J.L., Hark L., Igo R., Kang J.H., Kraft P., Lee R., Lichter P., Liu Y., Moroi S., Pasquale L.R., Pericak-Vance M., Realini A., Rhee D., Richards J.R., Ritch R., Schuman J., Scott W.K., Singh K., Sit A., Vollrath D., Weinreb R.N., Wollstein G., Zack D., Aung T., Burdon K.P., Cheng C.-Y., Bailey J.N.C., Craig J.E., Cree A.J., Hammond C.J., Hewitt A.W., H?hn R., Hysi P., Gonzalez A.I.I., Jonas J., Khawaja A., Khor C.-C., Klaver C.C.W., Pasutto F., Mackey D., Mitchell P., Mishra A., Pang C., Springelkamp H., Thorleifsson G., Thorsteinsdottir U., van Duijn C.M., Viswanathan A., Vitart V., Wojciechowski R., Wong T., Young T.L., Zeller T.
其他作者:	DUKE-NUS MEDICAL SCHOOL
格式:	Article
出版:	Public Library of Science 2020
主題:	proline POU6F2 protein, human transcription factor POU adult aged allele animal cell animal experiment animal model animal tissue Article cell death chromosome 13 chromosome 17 controlled study cornea thickness corneal limbal stem cell female gene gene identification genetic association genetic risk genome genomic locus male mouse nonhuman open angle glaucoma phenotype POU6F2 gene quantitative trait locus retina ganglion cell risk factor single nucleotide polymorphism stem cell anatomy and histology animal apoptosis C57BL mouse cell culture chromosomal mapping cornea corneal pachymetry DBA mouse disease model gene locus genetic predisposition genetics genome-wide association study glaucoma human mammalian embryo metabolism pathology physiology pregnancy transgenic mouse Animals Apoptosis Cells, Cultured Chromosome Mapping Cornea Corneal Pachymetry Disease Models, Animal Embryo, Mammalian Female Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Glaucoma Humans Male Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Transgenic Polymorphism, Single Nucleotide POU Domain Factors Pregnancy Retinal Ganglion Cells Risk Factors
在線閱讀:	https://scholarbank.nus.edu.sg/handle/10635/166155
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機構:	National University of Singapore

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https://scholarbank.nus.edu.sg/handle/10635/166155