Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma

• Main Authors: King R., Struebing F.L., Li Y., Wang J., Koch A.A., Cooke Bailey J.N., Gharahkhani P., MacGregor S., Allingham R.R., Hauser M.A., Wiggs J.L., Geisert E.E., Brilliant M., Budenz D., Bailey J.C., Fingert J., Gaasterland D., Gaasterland T., Haines J.L., Hark L., Igo R., Kang J.H., Kraft P., Lee R., Lichter P., Liu Y., Moroi S., Pasquale L.R., Pericak-Vance M., Realini A., Rhee D., Richards J.R., Ritch R., Schuman J., Scott W.K., Singh K., Sit A., Vollrath D., Weinreb R.N., Wollstein G., Zack D., Aung T., Burdon K.P., Cheng C.-Y., Bailey J.N.C., Craig J.E., Cree A.J., Hammond C.J., Hewitt A.W., H?hn R., Hysi P., Gonzalez A.I.I., Jonas J., Khawaja A., Khor C.-C., Klaver C.C.W., Pasutto F., Mackey D., Mitchell P., Mishra A., Pang C., Springelkamp H., Thorleifsson G., Thorsteinsdottir U., van Duijn C.M., Viswanathan A., Vitart V., Wojciechowski R., Wong T., Young T.L., Zeller T.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Public Library of Science 2020
• Subjects: proline; POU6F2 protein, human; transcription factor POU; adult; aged; allele; animal cell; animal experiment; animal model; animal tissue; Article; cell death; chromosome 13; chromosome 17; controlled study; cornea thickness; corneal limbal stem cell; female; gene; gene identification; genetic association; genetic risk; genome; genomic locus; male; mouse; nonhuman; open angle glaucoma; phenotype; POU6F2 gene; quantitative trait locus; retina ganglion cell; risk factor; single nucleotide polymorphism; stem cell; anatomy and histology; animal; apoptosis; C57BL mouse; cell culture; chromosomal mapping; cornea; corneal pachymetry; DBA mouse; disease model; gene locus; genetic predisposition; genetics; genome-wide association study; glaucoma; human; mammalian embryo; metabolism; pathology; physiology; pregnancy; transgenic mouse; Animals; Apoptosis; Cells, Cultured; Chromosome Mapping; Cornea; Corneal Pachymetry; Disease Models, Animal; Embryo, Mammalian; Female; Genetic Loci; Genetic Predisposition to Disease; Genome-Wide Association Study; Glaucoma; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Polymorphism, Single Nucleotide; POU Domain Factors; Pregnancy; Retinal Ganglion Cells; Risk Factors
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/166155
• Institution: National University of Singapore

10.1371/journal.pgen.1007145