Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma

10.1371/journal.pgen.1007145

Saved in:

Bibliographic Details
Main Authors:	King R., Struebing F.L., Li Y., Wang J., Koch A.A., Cooke Bailey J.N., Gharahkhani P., MacGregor S., Allingham R.R., Hauser M.A., Wiggs J.L., Geisert E.E., Brilliant M., Budenz D., Bailey J.C., Fingert J., Gaasterland D., Gaasterland T., Haines J.L., Hark L., Igo R., Kang J.H., Kraft P., Lee R., Lichter P., Liu Y., Moroi S., Pasquale L.R., Pericak-Vance M., Realini A., Rhee D., Richards J.R., Ritch R., Schuman J., Scott W.K., Singh K., Sit A., Vollrath D., Weinreb R.N., Wollstein G., Zack D., Aung T., Burdon K.P., Cheng C.-Y., Bailey J.N.C., Craig J.E., Cree A.J., Hammond C.J., Hewitt A.W., H?hn R., Hysi P., Gonzalez A.I.I., Jonas J., Khawaja A., Khor C.-C., Klaver C.C.W., Pasutto F., Mackey D., Mitchell P., Mishra A., Pang C., Springelkamp H., Thorleifsson G., Thorsteinsdottir U., van Duijn C.M., Viswanathan A., Vitart V., Wojciechowski R., Wong T., Young T.L., Zeller T.
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Public Library of Science 2020
Subjects:	proline POU6F2 protein, human transcription factor POU adult aged allele animal cell animal experiment animal model animal tissue Article cell death chromosome 13 chromosome 17 controlled study cornea thickness corneal limbal stem cell female gene gene identification genetic association genetic risk genome genomic locus male mouse nonhuman open angle glaucoma phenotype POU6F2 gene quantitative trait locus retina ganglion cell risk factor single nucleotide polymorphism stem cell anatomy and histology animal apoptosis C57BL mouse cell culture chromosomal mapping cornea corneal pachymetry DBA mouse disease model gene locus genetic predisposition genetics genome-wide association study glaucoma human mammalian embryo metabolism pathology physiology pregnancy transgenic mouse Animals Apoptosis Cells, Cultured Chromosome Mapping Cornea Corneal Pachymetry Disease Models, Animal Embryo, Mammalian Female Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Glaucoma Humans Male Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Transgenic Polymorphism, Single Nucleotide POU Domain Factors Pregnancy Retinal Ganglion Cells Risk Factors
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/166155
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	National University of Singapore

id	sg-nus-scholar.10635-166155
record_format	dspace
spelling	sg-nus-scholar.10635-1661552024-11-14T05:32:30Z Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma King R. Struebing F.L. Li Y. Wang J. Koch A.A. Cooke Bailey J.N. Gharahkhani P. MacGregor S. Allingham R.R. Hauser M.A. Wiggs J.L. Geisert E.E. Brilliant M. Budenz D. Bailey J.C. Fingert J. Gaasterland D. Gaasterland T. Haines J.L. Hark L. Igo R. Kang J.H. Kraft P. Lee R. Lichter P. Liu Y. Moroi S. Pasquale L.R. Pericak-Vance M. Realini A. Rhee D. Richards J.R. Ritch R. Schuman J. Scott W.K. Singh K. Sit A. Vollrath D. Weinreb R.N. Wollstein G. Zack D. Aung T. Burdon K.P. Cheng C.-Y. Bailey J.N.C. Craig J.E. Cree A.J. Hammond C.J. Hewitt A.W. H?hn R. Hysi P. Gonzalez A.I.I. Jonas J. Khawaja A. Khor C.-C. Klaver C.C.W. Pasutto F. Mackey D. Mitchell P. Mishra A. Pang C. Springelkamp H. Thorleifsson G. Thorsteinsdottir U. van Duijn C.M. Viswanathan A. Vitart V. Wojciechowski R. Wong T. Young T.L. Zeller T. DUKE-NUS MEDICAL SCHOOL proline POU6F2 protein, human transcription factor POU adult aged allele animal cell animal experiment animal model animal tissue Article cell death chromosome 13 chromosome 17 controlled study cornea thickness corneal limbal stem cell female gene gene identification genetic association genetic risk genome genomic locus male mouse nonhuman open angle glaucoma phenotype POU6F2 gene quantitative trait locus retina ganglion cell risk factor single nucleotide polymorphism stem cell anatomy and histology animal apoptosis C57BL mouse cell culture chromosomal mapping cornea corneal pachymetry DBA mouse disease model gene locus genetic predisposition genetics genome-wide association study glaucoma human mammalian embryo metabolism pathology physiology pregnancy transgenic mouse Animals Apoptosis Cells, Cultured Chromosome Mapping Cornea Corneal Pachymetry Disease Models, Animal Embryo, Mammalian Female Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Glaucoma Humans Male Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Transgenic Polymorphism, Single Nucleotide POU Domain Factors Pregnancy Retinal Ganglion Cells Risk Factors 10.1371/journal.pgen.1007145 PLoS Genetics 14 1 e1007145 2020-03-30T07:26:23Z 2020-03-30T07:26:23Z 2018 Article King R., Struebing F.L., Li Y., Wang J., Koch A.A., Cooke Bailey J.N., Gharahkhani P., MacGregor S., Allingham R.R., Hauser M.A., Wiggs J.L., Geisert E.E., Allingham R., Brilliant M., Budenz D., Bailey J.C., Fingert J., Gaasterland D., Gaasterland T., Haines J.L., Hark L., Hauser M., Igo R., Kang J.H., Kraft P., Lee R., Lichter P., Liu Y., Moroi S., Pasquale L.R., Pericak-Vance M., Realini A., Rhee D., Richards J.R., Ritch R., Schuman J., Scott W.K., Singh K., Sit A., Vollrath D., Weinreb R.N., Wollstein G., Zack D., Aung T., Burdon K.P., Cheng C.-Y., Bailey J.N.C., Craig J.E., Cree A.J., Hammond C.J., Hewitt A.W., H?hn R., Hysi P., Gonzalez A.I.I., Jonas J., Khawaja A., Khor C.-C., Klaver C.C.W., Pasutto F., Mackey D., Mitchell P., Mishra A., Pang C., Springelkamp H., Thorleifsson G., Thorsteinsdottir U., van Duijn C.M., Viswanathan A., Vitart V., Wojciechowski R., Wong T., Young T.L., Zeller T. (2018). Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma. PLoS Genetics 14 (1) : e1007145. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pgen.1007145 15537390 https://scholarbank.nus.edu.sg/handle/10635/166155 Public Library of Science Unpaywall 20200320
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	proline POU6F2 protein, human transcription factor POU adult aged allele animal cell animal experiment animal model animal tissue Article cell death chromosome 13 chromosome 17 controlled study cornea thickness corneal limbal stem cell female gene gene identification genetic association genetic risk genome genomic locus male mouse nonhuman open angle glaucoma phenotype POU6F2 gene quantitative trait locus retina ganglion cell risk factor single nucleotide polymorphism stem cell anatomy and histology animal apoptosis C57BL mouse cell culture chromosomal mapping cornea corneal pachymetry DBA mouse disease model gene locus genetic predisposition genetics genome-wide association study glaucoma human mammalian embryo metabolism pathology physiology pregnancy transgenic mouse Animals Apoptosis Cells, Cultured Chromosome Mapping Cornea Corneal Pachymetry Disease Models, Animal Embryo, Mammalian Female Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Glaucoma Humans Male Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Transgenic Polymorphism, Single Nucleotide POU Domain Factors Pregnancy Retinal Ganglion Cells Risk Factors
spellingShingle	proline POU6F2 protein, human transcription factor POU adult aged allele animal cell animal experiment animal model animal tissue Article cell death chromosome 13 chromosome 17 controlled study cornea thickness corneal limbal stem cell female gene gene identification genetic association genetic risk genome genomic locus male mouse nonhuman open angle glaucoma phenotype POU6F2 gene quantitative trait locus retina ganglion cell risk factor single nucleotide polymorphism stem cell anatomy and histology animal apoptosis C57BL mouse cell culture chromosomal mapping cornea corneal pachymetry DBA mouse disease model gene locus genetic predisposition genetics genome-wide association study glaucoma human mammalian embryo metabolism pathology physiology pregnancy transgenic mouse Animals Apoptosis Cells, Cultured Chromosome Mapping Cornea Corneal Pachymetry Disease Models, Animal Embryo, Mammalian Female Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Glaucoma Humans Male Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Transgenic Polymorphism, Single Nucleotide POU Domain Factors Pregnancy Retinal Ganglion Cells Risk Factors King R. Struebing F.L. Li Y. Wang J. Koch A.A. Cooke Bailey J.N. Gharahkhani P. MacGregor S. Allingham R.R. Hauser M.A. Wiggs J.L. Geisert E.E. Brilliant M. Budenz D. Bailey J.C. Fingert J. Gaasterland D. Gaasterland T. Haines J.L. Hark L. Igo R. Kang J.H. Kraft P. Lee R. Lichter P. Liu Y. Moroi S. Pasquale L.R. Pericak-Vance M. Realini A. Rhee D. Richards J.R. Ritch R. Schuman J. Scott W.K. Singh K. Sit A. Vollrath D. Weinreb R.N. Wollstein G. Zack D. Aung T. Burdon K.P. Cheng C.-Y. Bailey J.N.C. Craig J.E. Cree A.J. Hammond C.J. Hewitt A.W. H?hn R. Hysi P. Gonzalez A.I.I. Jonas J. Khawaja A. Khor C.-C. Klaver C.C.W. Pasutto F. Mackey D. Mitchell P. Mishra A. Pang C. Springelkamp H. Thorleifsson G. Thorsteinsdottir U. van Duijn C.M. Viswanathan A. Vitart V. Wojciechowski R. Wong T. Young T.L. Zeller T. Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma
description	10.1371/journal.pgen.1007145
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL King R. Struebing F.L. Li Y. Wang J. Koch A.A. Cooke Bailey J.N. Gharahkhani P. MacGregor S. Allingham R.R. Hauser M.A. Wiggs J.L. Geisert E.E. Brilliant M. Budenz D. Bailey J.C. Fingert J. Gaasterland D. Gaasterland T. Haines J.L. Hark L. Igo R. Kang J.H. Kraft P. Lee R. Lichter P. Liu Y. Moroi S. Pasquale L.R. Pericak-Vance M. Realini A. Rhee D. Richards J.R. Ritch R. Schuman J. Scott W.K. Singh K. Sit A. Vollrath D. Weinreb R.N. Wollstein G. Zack D. Aung T. Burdon K.P. Cheng C.-Y. Bailey J.N.C. Craig J.E. Cree A.J. Hammond C.J. Hewitt A.W. H?hn R. Hysi P. Gonzalez A.I.I. Jonas J. Khawaja A. Khor C.-C. Klaver C.C.W. Pasutto F. Mackey D. Mitchell P. Mishra A. Pang C. Springelkamp H. Thorleifsson G. Thorsteinsdottir U. van Duijn C.M. Viswanathan A. Vitart V. Wojciechowski R. Wong T. Young T.L. Zeller T.
format	Article
author	King R. Struebing F.L. Li Y. Wang J. Koch A.A. Cooke Bailey J.N. Gharahkhani P. MacGregor S. Allingham R.R. Hauser M.A. Wiggs J.L. Geisert E.E. Brilliant M. Budenz D. Bailey J.C. Fingert J. Gaasterland D. Gaasterland T. Haines J.L. Hark L. Igo R. Kang J.H. Kraft P. Lee R. Lichter P. Liu Y. Moroi S. Pasquale L.R. Pericak-Vance M. Realini A. Rhee D. Richards J.R. Ritch R. Schuman J. Scott W.K. Singh K. Sit A. Vollrath D. Weinreb R.N. Wollstein G. Zack D. Aung T. Burdon K.P. Cheng C.-Y. Bailey J.N.C. Craig J.E. Cree A.J. Hammond C.J. Hewitt A.W. H?hn R. Hysi P. Gonzalez A.I.I. Jonas J. Khawaja A. Khor C.-C. Klaver C.C.W. Pasutto F. Mackey D. Mitchell P. Mishra A. Pang C. Springelkamp H. Thorleifsson G. Thorsteinsdottir U. van Duijn C.M. Viswanathan A. Vitart V. Wojciechowski R. Wong T. Young T.L. Zeller T.
author_sort	King R.
title	Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma
title_short	Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma
title_full	Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma
title_fullStr	Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma
title_full_unstemmed	Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma
title_sort	genomic locus modulating corneal thickness in the mouse identifies pou6f2 as a potential risk of developing glaucoma
publisher	Public Library of Science
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/166155
_version_	1821211517067984896

Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma

Similar Items