Interleukin-1β attenuates myofibroblast formation and extracellular matrix production in dermal and lung fibroblasts exposed to transforming growth factor-β1

• Main Authors: Mia M.M., Boersema M., Bank R.A.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: alpha smooth muscle actin; collagen type 1; collagen type 3; collagen type I alpha 1; collagen type III alpha 1; gelatinase A; gelatinase B; interleukin 1beta; interstitial collagenase; matrix metalloproteinase 14; messenger RNA; procollagen lysine 2 oxoglutarate 5 dioxygenase; procollagen proline 2 oxoglutarate 4 dioxygenase; protein lysine 6 oxidase; transcription factor Gli1; transforming growth factor beta1; transgelin; unclassified drug; COL3A1 protein, human; Gli protein; matrix metalloproteinase; oncoprotein; sonic hedgehog protein; TGFB1 protein, human; transactivator protein; adult; article; cell transformation; collagen synthesis; controlled study; extracellular matrix; fibrosis; gene expression; human; human cell; lung fibroblast; myofibroblast; skin fibroblast; upregulation; biosynthesis; cell differentiation; cytology; dose response; drug effects; drug interaction; fibroblast; gene expression regulation; genetics; lung; metabolism; signal transduction; skin; Cell Differentiation; Collagen Type I; Collagen Type III; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Matrix; Fibroblasts; Gene Expression Regulation, Enzymologic; Hedgehog Proteins; Humans; Interleukin-1beta; Lung; Matrix Metalloproteinases; Myofibroblasts; Oncogene Proteins; Signal Transduction; Skin; Trans-Activators; Transforming Growth Factor beta1
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161426
• Institution: National University of Singapore

10.1371/journal.pone.0091559