Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects

10.1371/journal.pone.0089397

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Main Authors:	Bard-Chapeau E.A., Szumska D., Jacob B., Chua B.Q.L., Chatterjee G.C., Zhang Y., Ward J.M., Urun F., Kinameri E., Vincent S.D., Ahmed S., Bhattacharya S., Osato M., Perkins A.S., Moore A.W., Jenkins N.A., Copeland N.G.
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	2019
Subjects:	adult allele amino terminal sequence animal cell animal experiment animal model animal tissue article binding site congenital heart malformation controlled study disease severity embryo embryo development EVI1 gene exon gene deletion gene function gene identification gene location gene silencing gene targeting germ line hematopoietic cell heterozygote lethality mouse newborn nonhuman perinatal period phenotype regulator gene transcription initiation site Alleles Animals Animals, Newborn Base Sequence Bone Marrow Disease Models, Animal DNA-Binding Proteins Exons Gene Deletion Gene Expression Regulation, Developmental Genes, Lethal Genetic Association Studies Heart Defects, Congenital Hematopoiesis Hematopoietic Stem Cells Immunophenotyping Mice Mice, Knockout Molecular Sequence Data Mutation Phenotype Proto-Oncogenes Sequence Alignment Severity of Illness Index Transcription Factors
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161427
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1614272023-10-31T20:37:31Z Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects Bard-Chapeau E.A. Szumska D. Jacob B. Chua B.Q.L. Chatterjee G.C. Zhang Y. Ward J.M. Urun F. Kinameri E. Vincent S.D. Ahmed S. Bhattacharya S. Osato M. Perkins A.S. Moore A.W. Jenkins N.A. Copeland N.G. CANCER SCIENCE INSTITUTE OF SINGAPORE adult allele amino terminal sequence animal cell animal experiment animal model animal tissue article binding site congenital heart malformation controlled study disease severity embryo embryo development EVI1 gene exon gene deletion gene function gene identification gene location gene silencing gene targeting germ line hematopoietic cell heterozygote lethality mouse newborn nonhuman perinatal period phenotype regulator gene transcription initiation site Alleles Animals Animals, Newborn Base Sequence Bone Marrow Disease Models, Animal DNA-Binding Proteins Exons Gene Deletion Gene Expression Regulation, Developmental Genes, Lethal Genetic Association Studies Heart Defects, Congenital Hematopoiesis Hematopoietic Stem Cells Immunophenotyping Mice Mice, Knockout Molecular Sequence Data Mutation Phenotype Proto-Oncogenes Sequence Alignment Severity of Illness Index Transcription Factors 10.1371/journal.pone.0089397 PLoS ONE 9 2 e89397 2019-11-05T02:03:06Z 2019-11-05T02:03:06Z 2014 Article Bard-Chapeau E.A., Szumska D., Jacob B., Chua B.Q.L., Chatterjee G.C., Zhang Y., Ward J.M., Urun F., Kinameri E., Vincent S.D., Ahmed S., Bhattacharya S., Osato M., Perkins A.S., Moore A.W., Jenkins N.A., Copeland N.G. (2014). Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects. PLoS ONE 9 (2) : e89397. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0089397 1932-6203 https://scholarbank.nus.edu.sg/handle/10635/161427 Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	adult allele amino terminal sequence animal cell animal experiment animal model animal tissue article binding site congenital heart malformation controlled study disease severity embryo embryo development EVI1 gene exon gene deletion gene function gene identification gene location gene silencing gene targeting germ line hematopoietic cell heterozygote lethality mouse newborn nonhuman perinatal period phenotype regulator gene transcription initiation site Alleles Animals Animals, Newborn Base Sequence Bone Marrow Disease Models, Animal DNA-Binding Proteins Exons Gene Deletion Gene Expression Regulation, Developmental Genes, Lethal Genetic Association Studies Heart Defects, Congenital Hematopoiesis Hematopoietic Stem Cells Immunophenotyping Mice Mice, Knockout Molecular Sequence Data Mutation Phenotype Proto-Oncogenes Sequence Alignment Severity of Illness Index Transcription Factors
spellingShingle	adult allele amino terminal sequence animal cell animal experiment animal model animal tissue article binding site congenital heart malformation controlled study disease severity embryo embryo development EVI1 gene exon gene deletion gene function gene identification gene location gene silencing gene targeting germ line hematopoietic cell heterozygote lethality mouse newborn nonhuman perinatal period phenotype regulator gene transcription initiation site Alleles Animals Animals, Newborn Base Sequence Bone Marrow Disease Models, Animal DNA-Binding Proteins Exons Gene Deletion Gene Expression Regulation, Developmental Genes, Lethal Genetic Association Studies Heart Defects, Congenital Hematopoiesis Hematopoietic Stem Cells Immunophenotyping Mice Mice, Knockout Molecular Sequence Data Mutation Phenotype Proto-Oncogenes Sequence Alignment Severity of Illness Index Transcription Factors Bard-Chapeau E.A. Szumska D. Jacob B. Chua B.Q.L. Chatterjee G.C. Zhang Y. Ward J.M. Urun F. Kinameri E. Vincent S.D. Ahmed S. Bhattacharya S. Osato M. Perkins A.S. Moore A.W. Jenkins N.A. Copeland N.G. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects
description	10.1371/journal.pone.0089397
author2	CANCER SCIENCE INSTITUTE OF SINGAPORE
author_facet	CANCER SCIENCE INSTITUTE OF SINGAPORE Bard-Chapeau E.A. Szumska D. Jacob B. Chua B.Q.L. Chatterjee G.C. Zhang Y. Ward J.M. Urun F. Kinameri E. Vincent S.D. Ahmed S. Bhattacharya S. Osato M. Perkins A.S. Moore A.W. Jenkins N.A. Copeland N.G.
format	Article
author	Bard-Chapeau E.A. Szumska D. Jacob B. Chua B.Q.L. Chatterjee G.C. Zhang Y. Ward J.M. Urun F. Kinameri E. Vincent S.D. Ahmed S. Bhattacharya S. Osato M. Perkins A.S. Moore A.W. Jenkins N.A. Copeland N.G.
author_sort	Bard-Chapeau E.A.
title	Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects
title_short	Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects
title_full	Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects
title_fullStr	Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects
title_full_unstemmed	Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects
title_sort	mice carrying a hypomorphic evi1 allele are embryonic viable but exhibit severe congenital heart defects
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161427
_version_	1781791758929100800

Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects

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