AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes

• Main Authors: Jenkins Y., Sun T.-Q., Markovtsov V., Foretz M., Li W., Nguyen H., Li Y., Pan A., Uy G., Gross L., Baltgalvis K., Yung S.L., Gururaja T., Kinoshita T., Owyang A., Smith I.J., McCaughey K., White K., Godinez G., Alcantara R., Choy C., Ren H., Basile R., Sweeny D.J., Xu X., Issakani S.D., Carroll D.C., Goff D.A., Shaw S.J., Singh R., Boros L.G., Laplante M.-A., Marcotte B., Kohen R., Viollet B., Marette A., Payan D.G., Kinsella T.M., Hitoshi Y.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: branched chain amino acid; glucose; glucose c 13; hydroxymethylglutaryl coenzyme A reductase kinase; hydroxymethylglutaryl coenzyme A reductase kinase activator; metformin; palmitic acid c 13; r 419; radiopharmaceutical agent; reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone); unclassified drug; adipose tissue; animal cell; animal experiment; animal model; animal tissue; article; catabolism; concentration response; controlled study; diabetes mellitus; drug mechanism; drug potency; drug structure; enzyme activation; enzyme inhibition; fatty acid oxidation; gluconeogenesis; glucose homeostasis; glucose oxidation; glucose transport; human; human cell; in vitro study; in vivo study; lipid metabolism; lipogenesis; liver; male; metabolic parameters; metabolomics; mitochondrial respiration; mouse; muscle cell; nonhuman; nutrient dynamics; signal transduction; skeletal muscle; Amino Acids, Branched-Chain; AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Enzyme Activation; Fatty Acids; Glucose; Hep G2 Cells; Humans; Hypoglycemic Agents; Metformin; Mice; Mitochondria, Liver; Muscle Cells; Oxidation-Reduction; Palmitates; Protein Kinase Inhibitors
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161450
• Institution: National University of Singapore

10.1371/journal.pone.0081870