AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes

10.1371/journal.pone.0081870

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Main Authors:	Jenkins Y., Sun T.-Q., Markovtsov V., Foretz M., Li W., Nguyen H., Li Y., Pan A., Uy G., Gross L., Baltgalvis K., Yung S.L., Gururaja T., Kinoshita T., Owyang A., Smith I.J., McCaughey K., White K., Godinez G., Alcantara R., Choy C., Ren H., Basile R., Sweeny D.J., Xu X., Issakani S.D., Carroll D.C., Goff D.A., Shaw S.J., Singh R., Boros L.G., Laplante M.-A., Marcotte B., Kohen R., Viollet B., Marette A., Payan D.G., Kinsella T.M., Hitoshi Y.
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	2019
Subjects:	branched chain amino acid glucose glucose c 13 hydroxymethylglutaryl coenzyme A reductase kinase hydroxymethylglutaryl coenzyme A reductase kinase activator metformin palmitic acid c 13 r 419 radiopharmaceutical agent reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone) unclassified drug adipose tissue animal cell animal experiment animal model animal tissue article catabolism concentration response controlled study diabetes mellitus drug mechanism drug potency drug structure enzyme activation enzyme inhibition fatty acid oxidation gluconeogenesis glucose homeostasis glucose oxidation glucose transport human human cell in vitro study in vivo study lipid metabolism lipogenesis liver male metabolic parameters metabolomics mitochondrial respiration mouse muscle cell nonhuman nutrient dynamics signal transduction skeletal muscle Amino Acids, Branched-Chain AMP-Activated Protein Kinases Animals Diabetes Mellitus, Experimental Enzyme Activation Fatty Acids Glucose Hep G2 Cells Humans Hypoglycemic Agents Metformin Mice Mitochondria, Liver Muscle Cells Oxidation-Reduction Palmitates Protein Kinase Inhibitors
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161450
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1614502023-10-31T08:33:39Z AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes Jenkins Y. Sun T.-Q. Markovtsov V. Foretz M. Li W. Nguyen H. Li Y. Pan A. Uy G. Gross L. Baltgalvis K. Yung S.L. Gururaja T. Kinoshita T. Owyang A. Smith I.J. McCaughey K. White K. Godinez G. Alcantara R. Choy C. Ren H. Basile R. Sweeny D.J. Xu X. Issakani S.D. Carroll D.C. Goff D.A. Shaw S.J. Singh R. Boros L.G. Laplante M.-A. Marcotte B. Kohen R. Viollet B. Marette A. Payan D.G. Kinsella T.M. Hitoshi Y. DUKE-NUS MEDICAL SCHOOL branched chain amino acid glucose glucose c 13 hydroxymethylglutaryl coenzyme A reductase kinase hydroxymethylglutaryl coenzyme A reductase kinase activator metformin palmitic acid c 13 r 419 radiopharmaceutical agent reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone) unclassified drug adipose tissue animal cell animal experiment animal model animal tissue article catabolism concentration response controlled study diabetes mellitus drug mechanism drug potency drug structure enzyme activation enzyme inhibition fatty acid oxidation gluconeogenesis glucose homeostasis glucose oxidation glucose transport human human cell in vitro study in vivo study lipid metabolism lipogenesis liver male metabolic parameters metabolomics mitochondrial respiration mouse muscle cell nonhuman nutrient dynamics signal transduction skeletal muscle Amino Acids, Branched-Chain AMP-Activated Protein Kinases Animals Diabetes Mellitus, Experimental Enzyme Activation Fatty Acids Glucose Hep G2 Cells Humans Hypoglycemic Agents Metformin Mice Mitochondria, Liver Muscle Cells Oxidation-Reduction Palmitates Protein Kinase Inhibitors 10.1371/journal.pone.0081870 PLoS ONE 8 12 e81870 2019-11-05T02:08:34Z 2019-11-05T02:08:34Z 2013 Article Jenkins Y., Sun T.-Q., Markovtsov V., Foretz M., Li W., Nguyen H., Li Y., Pan A., Uy G., Gross L., Baltgalvis K., Yung S.L., Gururaja T., Kinoshita T., Owyang A., Smith I.J., McCaughey K., White K., Godinez G., Alcantara R., Choy C., Ren H., Basile R., Sweeny D.J., Xu X., Issakani S.D., Carroll D.C., Goff D.A., Shaw S.J., Singh R., Boros L.G., Laplante M.-A., Marcotte B., Kohen R., Viollet B., Marette A., Payan D.G., Kinsella T.M., Hitoshi Y. (2013). AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes. PLoS ONE 8 (12) : e81870. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0081870 1932-6203 https://scholarbank.nus.edu.sg/handle/10635/161450 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	branched chain amino acid glucose glucose c 13 hydroxymethylglutaryl coenzyme A reductase kinase hydroxymethylglutaryl coenzyme A reductase kinase activator metformin palmitic acid c 13 r 419 radiopharmaceutical agent reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone) unclassified drug adipose tissue animal cell animal experiment animal model animal tissue article catabolism concentration response controlled study diabetes mellitus drug mechanism drug potency drug structure enzyme activation enzyme inhibition fatty acid oxidation gluconeogenesis glucose homeostasis glucose oxidation glucose transport human human cell in vitro study in vivo study lipid metabolism lipogenesis liver male metabolic parameters metabolomics mitochondrial respiration mouse muscle cell nonhuman nutrient dynamics signal transduction skeletal muscle Amino Acids, Branched-Chain AMP-Activated Protein Kinases Animals Diabetes Mellitus, Experimental Enzyme Activation Fatty Acids Glucose Hep G2 Cells Humans Hypoglycemic Agents Metformin Mice Mitochondria, Liver Muscle Cells Oxidation-Reduction Palmitates Protein Kinase Inhibitors
spellingShingle	branched chain amino acid glucose glucose c 13 hydroxymethylglutaryl coenzyme A reductase kinase hydroxymethylglutaryl coenzyme A reductase kinase activator metformin palmitic acid c 13 r 419 radiopharmaceutical agent reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone) unclassified drug adipose tissue animal cell animal experiment animal model animal tissue article catabolism concentration response controlled study diabetes mellitus drug mechanism drug potency drug structure enzyme activation enzyme inhibition fatty acid oxidation gluconeogenesis glucose homeostasis glucose oxidation glucose transport human human cell in vitro study in vivo study lipid metabolism lipogenesis liver male metabolic parameters metabolomics mitochondrial respiration mouse muscle cell nonhuman nutrient dynamics signal transduction skeletal muscle Amino Acids, Branched-Chain AMP-Activated Protein Kinases Animals Diabetes Mellitus, Experimental Enzyme Activation Fatty Acids Glucose Hep G2 Cells Humans Hypoglycemic Agents Metformin Mice Mitochondria, Liver Muscle Cells Oxidation-Reduction Palmitates Protein Kinase Inhibitors Jenkins Y. Sun T.-Q. Markovtsov V. Foretz M. Li W. Nguyen H. Li Y. Pan A. Uy G. Gross L. Baltgalvis K. Yung S.L. Gururaja T. Kinoshita T. Owyang A. Smith I.J. McCaughey K. White K. Godinez G. Alcantara R. Choy C. Ren H. Basile R. Sweeny D.J. Xu X. Issakani S.D. Carroll D.C. Goff D.A. Shaw S.J. Singh R. Boros L.G. Laplante M.-A. Marcotte B. Kohen R. Viollet B. Marette A. Payan D.G. Kinsella T.M. Hitoshi Y. AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes
description	10.1371/journal.pone.0081870
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Jenkins Y. Sun T.-Q. Markovtsov V. Foretz M. Li W. Nguyen H. Li Y. Pan A. Uy G. Gross L. Baltgalvis K. Yung S.L. Gururaja T. Kinoshita T. Owyang A. Smith I.J. McCaughey K. White K. Godinez G. Alcantara R. Choy C. Ren H. Basile R. Sweeny D.J. Xu X. Issakani S.D. Carroll D.C. Goff D.A. Shaw S.J. Singh R. Boros L.G. Laplante M.-A. Marcotte B. Kohen R. Viollet B. Marette A. Payan D.G. Kinsella T.M. Hitoshi Y.
format	Article
author	Jenkins Y. Sun T.-Q. Markovtsov V. Foretz M. Li W. Nguyen H. Li Y. Pan A. Uy G. Gross L. Baltgalvis K. Yung S.L. Gururaja T. Kinoshita T. Owyang A. Smith I.J. McCaughey K. White K. Godinez G. Alcantara R. Choy C. Ren H. Basile R. Sweeny D.J. Xu X. Issakani S.D. Carroll D.C. Goff D.A. Shaw S.J. Singh R. Boros L.G. Laplante M.-A. Marcotte B. Kohen R. Viollet B. Marette A. Payan D.G. Kinsella T.M. Hitoshi Y.
author_sort	Jenkins Y.
title	AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes
title_short	AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes
title_full	AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes
title_fullStr	AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes
title_full_unstemmed	AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes
title_sort	ampk activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161450
_version_	1781791765655715840

AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes

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