Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle

• Main Authors: Julien S.G., Kim S.-Y., Brunmeir R., Sinnakannu J.R., Ge X., Li H., Ma W., Yaligar J., Bhanu Prakash K.N., Velan S.S., R�der P.V., Zhang Q., Sim C.K., Wu J., Garcia-Miralles M., Pouladi M.A., Xie W., McFarlane C., Han W., Xu F.
• 其他作者: MEDICINE
• 格式: Article
• 出版: 2019
• 主題: adenine nucleotide translocase; cyclic AMP; hydroxymethylglutaryl coenzyme A reductase kinase; narciclasine; reactive oxygen metabolite; adenosine diphosphate; adenosine triphosphate; Amaryllidaceae alkaloid; biological marker; fatty acid; phenanthridine derivative; protective agent; aerobic metabolism; animal cell; animal tissue; Article; blood cell; cell metabolism; controlled study; diet induced obesity; drug effect; energy expenditure; enzyme activation; enzyme synthesis; fatty acid oxidation; glycolysis; human; human tissue; in vitro study; lipid metabolism; male; metabolic clearance; mitochondrial membrane potential; mitochondrial respiration; mouse; muscle cell; myotube; nonhuman; physical activity; protein blood level; signal transduction; skeletal muscle; adverse effects; animal; animal experiment; C57BL mouse; cell culture; cell respiration; diet; drug effects; energy metabolism; lipid diet; metabolism; mitochondrion; obesity; oxidation reduction reaction; skeletal muscle cell; slow muscle fiber; Adenosine Diphosphate; Adenosine Triphosphate; Amaryllidaceae Alkaloids; AMP-Activated Protein Kinases; Animals; Biomarkers; Cell Respiration; Cells, Cultured; Cyclic AMP; Diet; Diet, High-Fat; Energy Metabolism; Enzyme Activation; Fatty Acids; Humans; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mitochondria; Muscle Fibers, Skeletal; Muscle Fibers, Slow-Twitch; Muscle, Skeletal; Obesity; Oxidation-Reduction; Phenanthridines; Physical Conditioning, Animal; Protective Agents; Reactive Oxygen Species; Signal Transduction
• 在線閱讀: https://scholarbank.nus.edu.sg/handle/10635/161898

10.1371/journal.pbio.1002597