Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle

10.1371/journal.pbio.1002597

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Main Authors:	Julien S.G., Kim S.-Y., Brunmeir R., Sinnakannu J.R., Ge X., Li H., Ma W., Yaligar J., Bhanu Prakash K.N., Velan S.S., R�der P.V., Zhang Q., Sim C.K., Wu J., Garcia-Miralles M., Pouladi M.A., Xie W., McFarlane C., Han W., Xu F.
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	2019
Subjects:	adenine nucleotide translocase cyclic AMP hydroxymethylglutaryl coenzyme A reductase kinase narciclasine reactive oxygen metabolite adenosine diphosphate adenosine triphosphate Amaryllidaceae alkaloid biological marker fatty acid phenanthridine derivative protective agent aerobic metabolism animal cell animal tissue Article blood cell cell metabolism controlled study diet induced obesity drug effect energy expenditure enzyme activation enzyme synthesis fatty acid oxidation glycolysis human human tissue in vitro study lipid metabolism male metabolic clearance mitochondrial membrane potential mitochondrial respiration mouse muscle cell myotube nonhuman physical activity protein blood level signal transduction skeletal muscle adverse effects animal animal experiment C57BL mouse cell culture cell respiration diet drug effects energy metabolism lipid diet metabolism mitochondrion obesity oxidation reduction reaction skeletal muscle cell slow muscle fiber Adenosine Diphosphate Adenosine Triphosphate Amaryllidaceae Alkaloids AMP-Activated Protein Kinases Animals Biomarkers Cell Respiration Cells, Cultured Cyclic AMP Diet Diet, High-Fat Energy Metabolism Enzyme Activation Fatty Acids Humans Male Membrane Potential, Mitochondrial Mice Mice, Inbred C57BL Mitochondria Muscle Fibers, Skeletal Muscle Fibers, Slow-Twitch Muscle, Skeletal Obesity Oxidation-Reduction Phenanthridines Physical Conditioning, Animal Protective Agents Reactive Oxygen Species Signal Transduction
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161898
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1618982024-05-08T09:52:07Z Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle Julien S.G. Kim S.-Y. Brunmeir R. Sinnakannu J.R. Ge X. Li H. Ma W. Yaligar J. Bhanu Prakash K.N. Velan S.S. R�der P.V. Zhang Q. Sim C.K. Wu J. Garcia-Miralles M. Pouladi M.A. Xie W. McFarlane C. Han W. Xu F. CANCER SCIENCE INSTITUTE OF SINGAPORE MEDICINE DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) DUKE-NUS MEDICAL SCHOOL BIOCHEMISTRY PHYSIOLOGY adenine nucleotide translocase cyclic AMP hydroxymethylglutaryl coenzyme A reductase kinase narciclasine reactive oxygen metabolite adenosine diphosphate adenosine triphosphate Amaryllidaceae alkaloid biological marker cyclic AMP fatty acid hydroxymethylglutaryl coenzyme A reductase kinase narciclasine phenanthridine derivative protective agent reactive oxygen metabolite aerobic metabolism animal cell animal tissue Article blood cell cell metabolism controlled study diet induced obesity drug effect energy expenditure enzyme activation enzyme synthesis fatty acid oxidation glycolysis human human tissue in vitro study lipid metabolism male metabolic clearance mitochondrial membrane potential mitochondrial respiration mouse muscle cell myotube nonhuman physical activity protein blood level signal transduction skeletal muscle adverse effects animal animal experiment C57BL mouse cell culture cell respiration diet drug effects energy metabolism lipid diet metabolism mitochondrion obesity oxidation reduction reaction skeletal muscle skeletal muscle cell slow muscle fiber Adenosine Diphosphate Adenosine Triphosphate Amaryllidaceae Alkaloids AMP-Activated Protein Kinases Animals Biomarkers Cell Respiration Cells, Cultured Cyclic AMP Diet Diet, High-Fat Energy Metabolism Enzyme Activation Fatty Acids Humans Male Membrane Potential, Mitochondrial Mice Mice, Inbred C57BL Mitochondria Muscle Fibers, Skeletal Muscle Fibers, Slow-Twitch Muscle, Skeletal Obesity Oxidation-Reduction Phenanthridines Physical Conditioning, Animal Protective Agents Reactive Oxygen Species Signal Transduction 10.1371/journal.pbio.1002597 PLoS Biology 15 2 e1002597 2019-11-08T06:45:02Z 2019-11-08T06:45:02Z 2017 Article Julien S.G., Kim S.-Y., Brunmeir R., Sinnakannu J.R., Ge X., Li H., Ma W., Yaligar J., Bhanu Prakash K.N., Velan S.S., R�der P.V., Zhang Q., Sim C.K., Wu J., Garcia-Miralles M., Pouladi M.A., Xie W., McFarlane C., Han W., Xu F. (2017). Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle. PLoS Biology 15 (2) : e1002597. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pbio.1002597 15449173 https://scholarbank.nus.edu.sg/handle/10635/161898 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	adenine nucleotide translocase cyclic AMP hydroxymethylglutaryl coenzyme A reductase kinase narciclasine reactive oxygen metabolite adenosine diphosphate adenosine triphosphate Amaryllidaceae alkaloid biological marker cyclic AMP fatty acid hydroxymethylglutaryl coenzyme A reductase kinase narciclasine phenanthridine derivative protective agent reactive oxygen metabolite aerobic metabolism animal cell animal tissue Article blood cell cell metabolism controlled study diet induced obesity drug effect energy expenditure enzyme activation enzyme synthesis fatty acid oxidation glycolysis human human tissue in vitro study lipid metabolism male metabolic clearance mitochondrial membrane potential mitochondrial respiration mouse muscle cell myotube nonhuman physical activity protein blood level signal transduction skeletal muscle adverse effects animal animal experiment C57BL mouse cell culture cell respiration diet drug effects energy metabolism lipid diet metabolism mitochondrion obesity oxidation reduction reaction skeletal muscle skeletal muscle cell slow muscle fiber Adenosine Diphosphate Adenosine Triphosphate Amaryllidaceae Alkaloids AMP-Activated Protein Kinases Animals Biomarkers Cell Respiration Cells, Cultured Cyclic AMP Diet Diet, High-Fat Energy Metabolism Enzyme Activation Fatty Acids Humans Male Membrane Potential, Mitochondrial Mice Mice, Inbred C57BL Mitochondria Muscle Fibers, Skeletal Muscle Fibers, Slow-Twitch Muscle, Skeletal Obesity Oxidation-Reduction Phenanthridines Physical Conditioning, Animal Protective Agents Reactive Oxygen Species Signal Transduction
spellingShingle	adenine nucleotide translocase cyclic AMP hydroxymethylglutaryl coenzyme A reductase kinase narciclasine reactive oxygen metabolite adenosine diphosphate adenosine triphosphate Amaryllidaceae alkaloid biological marker cyclic AMP fatty acid hydroxymethylglutaryl coenzyme A reductase kinase narciclasine phenanthridine derivative protective agent reactive oxygen metabolite aerobic metabolism animal cell animal tissue Article blood cell cell metabolism controlled study diet induced obesity drug effect energy expenditure enzyme activation enzyme synthesis fatty acid oxidation glycolysis human human tissue in vitro study lipid metabolism male metabolic clearance mitochondrial membrane potential mitochondrial respiration mouse muscle cell myotube nonhuman physical activity protein blood level signal transduction skeletal muscle adverse effects animal animal experiment C57BL mouse cell culture cell respiration diet drug effects energy metabolism lipid diet metabolism mitochondrion obesity oxidation reduction reaction skeletal muscle skeletal muscle cell slow muscle fiber Adenosine Diphosphate Adenosine Triphosphate Amaryllidaceae Alkaloids AMP-Activated Protein Kinases Animals Biomarkers Cell Respiration Cells, Cultured Cyclic AMP Diet Diet, High-Fat Energy Metabolism Enzyme Activation Fatty Acids Humans Male Membrane Potential, Mitochondrial Mice Mice, Inbred C57BL Mitochondria Muscle Fibers, Skeletal Muscle Fibers, Slow-Twitch Muscle, Skeletal Obesity Oxidation-Reduction Phenanthridines Physical Conditioning, Animal Protective Agents Reactive Oxygen Species Signal Transduction Julien S.G. Kim S.-Y. Brunmeir R. Sinnakannu J.R. Ge X. Li H. Ma W. Yaligar J. Bhanu Prakash K.N. Velan S.S. R�der P.V. Zhang Q. Sim C.K. Wu J. Garcia-Miralles M. Pouladi M.A. Xie W. McFarlane C. Han W. Xu F. Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle
description	10.1371/journal.pbio.1002597
author2	CANCER SCIENCE INSTITUTE OF SINGAPORE
author_facet	CANCER SCIENCE INSTITUTE OF SINGAPORE Julien S.G. Kim S.-Y. Brunmeir R. Sinnakannu J.R. Ge X. Li H. Ma W. Yaligar J. Bhanu Prakash K.N. Velan S.S. R�der P.V. Zhang Q. Sim C.K. Wu J. Garcia-Miralles M. Pouladi M.A. Xie W. McFarlane C. Han W. Xu F.
format	Article
author	Julien S.G. Kim S.-Y. Brunmeir R. Sinnakannu J.R. Ge X. Li H. Ma W. Yaligar J. Bhanu Prakash K.N. Velan S.S. R�der P.V. Zhang Q. Sim C.K. Wu J. Garcia-Miralles M. Pouladi M.A. Xie W. McFarlane C. Han W. Xu F.
author_sort	Julien S.G.
title	Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle
title_short	Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle
title_full	Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle
title_fullStr	Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle
title_full_unstemmed	Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle
title_sort	narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161898
_version_	1800913825666433024

Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle

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